|
Abnormality of blood and blood-forming tissues
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The monocyte-derived cytokines interleukin (IL)-17, IL-1β, IL-6 and tumour necrosis factor-α mediated by the induction of Card9 markedly increased in SAP patients compared with the control group.
|
26893103 |
2016 |
|
Acute pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF-κB and P38MAPKs pathway.
|
27957800 |
2017 |
|
Ankylosing spondylitis
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
However, we observed that CARD9 allele C (p = 0.012) and genotype CC (p = 0.012) were significant protective factors against AS only in HLA-B27-negative patients, and IL1R2 rs2310173 genotype GT was mildly protective against AS only in HLA-B27-negative status.
|
26590821 |
2016 |
|
Ankylosing spondylitis
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Our study confirmed that an SNP rs11145835 in 9q34.3 that harbors CARD9 and SNAPC4 is associated with AS in a Chinese Han population, and rs11145835 in SNAPC4 is a potential causal variant.
|
24334645 |
2014 |
|
Ankylosing spondylitis
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied).
|
21743469 |
2011 |
|
Ankylosing spondylitis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ankylosing spondylitis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Ankylosing spondylitis
|
0.440 |
Biomarker
|
disease |
CTD_human |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
|
Ankylosing spondylitis
|
0.440 |
Biomarker
|
disease |
BEFREE |
CARD9 is a plausible candidate for AS given its central role in the innate immune response.
|
20463747 |
2010 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We therefore evaluated whether hematopoietic deletion of Dectin-2 or CARD9 reduces inflammation and atherosclerosis development.
|
30867470 |
2019 |
|
Aspergillosis, Allergic Bronchopulmonary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified the homozygous CARD9 mutation encoding S12N in patients with allergic bronchopulmonary aspergillosis and revealed activation of RelB and production of IL-5 in peripheral blood mononuclear cells from these patients.
|
29777223 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We therefore evaluated whether hematopoietic deletion of Dectin-2 or CARD9 reduces inflammation and atherosclerosis development.
|
30867470 |
2019 |
|
Atherosclerotic lesion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, deletion of hematopoietic CARD9 increased atherosclerotic lesion formation and lesion severity.
|
30867470 |
2019 |
|
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Autoimmune Diseases
|
0.140 |
Biomarker
|
group |
BEFREE |
These findings suggest that targeting CARD9 may suppress the development of colitis and autoimmunity by reducing dendritic cell-driven inflammation.
|
31594855 |
2019 |
|
Autoimmune Diseases
|
0.140 |
Biomarker
|
group |
BEFREE |
Taken together, this report relates the potential of the Dectin-2/Card9-coupled pathway in ocular autoimmunity.
|
28763100 |
2017 |
|
Autoimmune Diseases
|
0.140 |
GeneticVariation
|
group |
BEFREE |
The single-nucleotide polymorphism rs4077515 at CARD9 in the human genome, which results in the substitution S12N (CARD9<sup>S12N</sup>), is associated with several autoimmune diseases.
|
29777223 |
2018 |
|
Autoimmune Diseases
|
0.140 |
Biomarker
|
group |
BEFREE |
Moreover, CARD9-dependent functions have recently been indicated to modulate the development of autoimmunity, inflammatory bowel diseases, and cancer.
|
30127791 |
2018 |
|
Autoimmune Diseases
|
0.140 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Autoimmune thrombocytopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A CARD9 single-nucleotide polymorphism rs4077515 is associated with reduced susceptibility to and severity of primary immune thrombocytopenia.
|
31595308 |
2019 |
|
Autoimmune thyroiditis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
B-Cell Lymphomas
|
0.020 |
Biomarker
|
group |
BEFREE |
Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule that is critical for NF-κB activation and forms a complex with B cell lymphoma 10 and mucosa-associated lymphoid tissue lymphoma translocation gene 1 that mediates C-type lectin receptors (CLRs)-triggered intracellular signaling during antifungal immunity.
|
25790941 |
2015 |