|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings provide essential tools required to define the role of BH in BLM-induced pulmonary fibrosis and BLM resistance in tumors.
|
9331073 |
1997 |
|
Pulmonary Fibrosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings provide essential tools required to define the role of BH in BLM-induced pulmonary fibrosis and BLM resistance in tumors.
|
9331073 |
1997 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, Southern blot analysis of DNA from leukocytes and autologous breast tumors has shown that the bleomycin hydrolase gene is not a frequent target of amplification in human breast carcinomas.
|
9407121 |
1997 |
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Finally, Southern blot analysis of DNA from leukocytes and autologous breast tumors has shown that the bleomycin hydrolase gene is not a frequent target of amplification in human breast carcinomas.
|
9407121 |
1997 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype.
|
9818937 |
1998 |
|
Pulmonary Fibrosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Compared with controls, Blmh null mice were more sensitive to acute BLM lethality and developed pulmonary fibrosis more readily following BLM treatment.
|
10200322 |
1999 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice lacking Blmh exhibited variably penetrant tail dermatitis that resembled rodent ringtail.
|
10200322 |
1999 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In addition, apolipoprotein E gene allele E4 and the bleomycin hydrolase locus are shown to be genetic risk factors for late-onset AD in certain sporadic cases.
|
10230703 |
1999 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
These findings support a key proximal role for bleomycin hydrolase, and oxidative stress in AD.
|
10363952 |
1999 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
However, no direct association was observed between the -491A/T or BH-PEN polymorphism and AD.
|
10530514 |
1999 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Additional studies should be undertaken to increase the confidence that the BH polymorphism is associated with AD and to explore the relationship between BH and apoE.
|
10822352 |
2000 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the genetic factors for AD among a Chinese population in Taiwan, we studied the polymorphisms of six candidate genes of Alzheimer's disease (AD), including the regulatory region of apolipoprotein E (Apo-E, G-186T), the promoter of apolipoprotein E (Apo-E, A-491T), the bleomycin hydrolase gene (BH, A1450G), a mutation of alpha(2)-macroglobulin gene (A2M G2998A), low-density lipoprotein receptor-related protein gene (LRP, C766T), and alpha(1)-antichymotrypsin gene (ACT, -15Ala/Thr) in AD patients and non-affected elder individuals among Taiwanese Chinese.
|
11099722 |
2000 |
|
Pulmonary Fibrosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Functional studies of bleomycin hydrolase activity indicate that this enzyme modulates bleomycin-induced pulmonary fibrosis, suggesting that it may be a candidate gene for Blmpf2.
|
12140188 |
2002 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
LHGDN |
To further investigate, we have analyzed association between the apolipoprotein E (apo E) and bleomycin hydrolase (BH) polymorphisms and three groups of elderly patients: control subjects (T) (n = 68), late-onset sporadic DTA patients (DTAst) (n = 65) and other non vascular neurodegerative diseases (MNDA) (n = 52).
|
12604387 |
2003 |
|
Neurodegenerative Disorders
|
0.010 |
GeneticVariation
|
group |
LHGDN |
[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases].
|
12604387 |
2003 |
|
Alzheimer Disease, Late Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variants of the interleukin-6, bleomycin hydrolase and alpha(2)-macroglobulin genes did not significantly influence the (age-adjusted) risk of AD in relatives.
|
15211070 |
2004 |
|
Germ Cell Cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients.
|
15900213 |
2005 |
|
Malignant Testicular Germ Cell Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
BLMH gene SNP A1450G has a significant effect on TC-related survival (log-rank P = .001).
|
18398146 |
2008 |
|
Narcolepsy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association database developed in the Japanese Integrated Database Project.
|
19629137 |
2009 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
No association was observed between carrying the BLMH-G genotype and AD in ε4 negative or positive subjects.
|
20198498 |
2010 |
|
Alzheimer's Disease
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that diminished functional BLH activity could contribute to the pathology of AD.
|
20308784 |
2010 |
|
Dermatitis, Atopic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the transcriptional regulatory mechanisms of BH and the relevance of BH to AD.
|
21190945 |
2011 |
|
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the transcriptional regulatory mechanisms of BH and the relevance of BH to AD.
|
21190945 |
2011 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.
|
21943823 |
2011 |
|
Liver carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.
|
21943823 |
2011 |