Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, variants of the hepatocanalicular cholesterol hemitransporters ABCG5/8 were linked to gallstone disease; ABCG8 D19H in Caucasians and ABCG5 Q604E in Chinese.
|
20497293 |
2010 |
Cholelithiasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ABCG5/8 cholesterol transporter and myocardial infarction versus gallstone disease.
|
24657701 |
2014 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recurrence of gallstones after cholecystectomy is associated with ABCG5/8 genotype.
|
22869156 |
2013 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ABCG5 rs6756629 is in strong linkage disequilibrium with rs11887534 (D19H), a variant previously associated with gallstone disease risk in populations of European-descent.
|
24256507 |
2013 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate a possible association between transporter gene polymorphism and gallstone formation, we examined five common polymorphisms in the ABCG5 (Q604E) and ABCG8 (D19H, Y54C, T400K, A632V) genes in patients with gallstone disease (GS).
|
17612515 |
2007 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Various polymorphisms (A632V, T400K, D19H, M429V, and C54Y) in the ABCG8 and ABCG5 (Q604E) gene have been found to be associated with several facets of cholesterol metabolism, including baseline cholesterol level, cholesterol kinetics, individual responsiveness of plasma cholesterol to dietary and pharmaceutical interventions for hypercholesterolemia, and increased risk of gallstones.
|
18522623 |
2008 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variations in STSL have been linked to lipid levels and gallstone disease in whites.
|
24811295 |
2014 |
Cholelithiasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study demonstrated TMAO could be associated with increased hepatic Abcg5/g8 expression, biliary cholesterol hypersecretion and gallstone formation.
|
31251986 |
2019 |
Cholelithiasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In PS bile acid concentration correlated with gallstone plant sterols (R = 0.83, P < 0.0001), and ABCG5 expression with ABCB11 expression (R = 0.27, P = 0.03).
|
31169656 |
2019 |
Cholelithiasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of ceramide biosynthesis by myriocin suppressed gallstone formation and ABCG5/8 mRNA expression.
|
28268212 |
2017 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers of ABCG5 604Q or ABCG8 D19H polymorphisms have an increased risk of gallstone disease independent of age, sex and body mass index.
|
18457353 |
2008 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The linkage and association studies identified the cholesterol transporter ABCG5/G8 as a genetic determinant of gallstone formation, or LITH gene, in humans.
|
17626266 |
2007 |
Cholelithiasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the prevalence of CL in Caucasian adult patients with GD1 and the possible risk factors, including gene variants of the ABCG5/ABCG8 genes.
|
27981300 |
2016 |
Cholelithiasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hepatic mRNA expression of ABCG5/G8 genes in 182 patients with gallstone disease and 35 gallstone-free patients who underwent cholecystectomy were determined using real-time PCR.
|
24498041 |
2014 |