Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Silencing the RHBDF1 gene with short interfering RNA (siRNA) results in apoptosis in breast cancer MDA-MB-435 cells and autophagy in head and neck squamous cell cancer 1483 cells.
|
18524845 |
2008 |
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Since early stages of breast cancer are characterized by the loss of mammary gland epithelial cell polarity, our findings indicate that perturbations of apicobasal polarity by high levels of RHBDF1 is a significant attribute in the development of breast neoplasia.-Peng, X.-M., Gao, S., Deng, H.-T., Cai, H.-X., Zhou, Z., Xiang, R., Zhang, Q.-Z., Li, L.-Y.
|
29727209 |
2018 |
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
RHBDF1 was silenced in various breast cancer cells using shRNA.
|
30279141 |
2018 |
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
ErbB2 (epidermal growth factor receptor-related protein B2) is frequently overexpressed in human breast cancer and is sufficient for mammary tumorigenesis in vivo.
|
12810676 |
2003 |
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We report here that RHBDF1 expression in breast cancer is highly elevated and is strongly correlated with escalated disease progression, metastasis, poor prognosis, and poor response to chemotherapy.
|
24648344 |
2014 |
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Targeting proteins involved in vesicular transport like Rab GTPases, the neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9), runt-related transcription factor 2 (RUNX2), human rhomboid family-1 (RHBDF1), monocarboxylate transporter 4, etc., would aid in designing improved therapeutics for the treatment of breast cancer.
|
31828433 |
2020 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We show here that a novel gene, human rhomboid family-1 (RHBDF1), which was recently reported to have a pivotal role in epithelial cancer cell growth in culture and in xenograft tumors, participates in the modulation of GPCR-mediated EGFR transactivation.
|
18832597 |
2009 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Furthermore, silencing the RHBDF1 gene in MDA-MB-435 or 1483 xenograft tumors on athymic nude mice by using i.v. administered histidine-lysine polymer nanoparticle-encapsulated siRNA results in marked inhibition of tumor growth.
|
18524845 |
2008 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Intratumoral or subcutaneous (away from the tumor site) injections of purified epidermal growth factor receptor-related protein caused regression of palpable colon cancer xenograft tumors in some severely compromised immunodeficient mice and arrested tumor growth in others.
|
12730874 |
2003 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Increased expression of iRhom1, iRhom2, and K‑i67 was significantly associated with tumor stage, size, and parametrium invasion.
|
31661139 |
2020 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Since early stages of breast cancer are characterized by the loss of mammary gland epithelial cell polarity, our findings indicate that perturbations of apicobasal polarity by high levels of RHBDF1 is a significant attribute in the development of breast neoplasia.-Peng, X.-M., Gao, S., Deng, H.-T., Cai, H.-X., Zhou, Z., Xiang, R., Zhang, Q.-Z., Li, L.-Y.
|
29727209 |
2018 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Mean scores for ERRP expression decreased significantly across well differentiated, moderately well differentiated and poorly differentiated (P = 0.002) tumors, respectively.
|
15327841 |
2004 |
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
ErbB2 (epidermal growth factor receptor-related protein B2) is frequently overexpressed in human breast cancer and is sufficient for mammary tumorigenesis in vivo.
|
12810676 |
2003 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Targeting proteins involved in vesicular transport like Rab GTPases, the neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9), runt-related transcription factor 2 (RUNX2), human rhomboid family-1 (RHBDF1), monocarboxylate transporter 4, etc., would aid in designing improved therapeutics for the treatment of breast cancer.
|
31828433 |
2020 |
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We report here that RHBDF1 expression in breast cancer is highly elevated and is strongly correlated with escalated disease progression, metastasis, poor prognosis, and poor response to chemotherapy.
|
24648344 |
2014 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
RHBDF1 was silenced in various breast cancer cells using shRNA.
|
30279141 |
2018 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Silencing the RHBDF1 gene with short interfering RNA (siRNA) results in apoptosis in breast cancer MDA-MB-435 cells and autophagy in head and neck squamous cell cancer 1483 cells.
|
18524845 |
2008 |
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Since early stages of breast cancer are characterized by the loss of mammary gland epithelial cell polarity, our findings indicate that perturbations of apicobasal polarity by high levels of RHBDF1 is a significant attribute in the development of breast neoplasia.-Peng, X.-M., Gao, S., Deng, H.-T., Cai, H.-X., Zhou, Z., Xiang, R., Zhang, Q.-Z., Li, L.-Y.
|
29727209 |
2018 |
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Expression of ERRP in cancer cells inversely correlated with cell proliferation and grade of malignancy.
|
15647181 |
2005 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
RHBDF1 is an indispensable component of the protein trafficking machinery involved in GPCR-mediated EGFR transactivation, and is an attractive therapeutic target for cancer.
|
30279141 |
2018 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Silencing the RHBDF1 gene in head and neck squamous cancer cell line 1483 cells with siRNA causes an inhibition of gastrin-releasing peptide (GRP) -induced phosphorylation of EGFR and EGFR-dependent signaling proteins p44/42 MAPK and AKT, accompanied by an inhibition of GRP-induced survival, proliferation, and invasion of the cells.
|
18832597 |
2009 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Increased expression of iRhom1, iRhom2, and K‑i67 was significantly associated with tumor stage, size, and parametrium invasion.
|
31661139 |
2020 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
RHBDF1-dependent cell viability and invasion were measured.
|
30279141 |
2018 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer.
|
16885366 |
2006 |
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Expression of ERRP in cancer cells inversely correlated with cell proliferation and grade of malignancy.
|
15647181 |
2005 |