|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumour xenograft experiment in nude mice was used to detect the tumour growth, and the effects of miRNA-141 overexpression on YAP1 and SOX17 were analysed using Western blot.
|
30599110 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the mouse studies, knockdown of miR‑194‑5p suppressed tumor growth and promoted SOX17 expression in nude mice with breast cancer.
|
30272253 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, our data demonstrated that SOX17 restrained the proliferation and tumor formation by down-regulating the activity of the Wnt/β-catenin signaling pathway via trans-suppression of β-catenin in cervical cancer.
|
29970906 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, SOX17 expression correlates with the outcome of patients after tumor resection, being a potential prognostic biomarker.
|
28237397 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Only rare tumor cells were positive for SOX17.
|
28614211 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SOX17 is a developmental transcription factor necessary for proper endoderm formation that has been implicated as a tumor suppressor and shown to modulate WNT signaling.
|
28978154 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The over-expression of tumour suppressor genes such as RB and SOX17 and down-regulation of an oncogene such as SOX2 were in accordance to the inhibitory role of miR-340 that causes blockage of breast cancer metastasis which should be further investigated.
|
27229858 |
2017 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
SOX17 promoter methylation in plasma circulating tumor DNA of patients with non-small cell lung cancer.
|
26741346 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that decreasing SOX17 levels may promote EC development and progression, and that by downregulating MAML3 expression and Wnt signaling, SOX17 acts as a tumor suppressor that may improve outcome in patients with EC.
|
27738313 |
2016 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Aberrant Sox17 methylation in cancer tissues and in plasma DNA was significantly associated with the tumor node metastasis stage (P = 0.035 and P = 0.001, respectively) and with lymph node metastasis (P < 0.001 and P = 0.001, respectively).
|
25789956 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the lack of SOX17 protein expression was strongly correlated with higher tumor grade (P = 0.002), lymph node metastasis (P < 0.001), and tumor node metastasis (TNM) stage (P = 0.001) and had poorer disease-free survival (DFS) and overall survival (OS) compared to normal SOX17 expression (P = 0.002 and 0.001, respectively).
|
25971583 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Clustering also defined a hypermethylated luminal-enriched tumor cluster 3 that gene ontology analysis revealed to be enriched for homeobox and other developmental genes (ASCL2, DLK1, EYA4, GAS7, HOXA5, HOXA9, HOXB13, IHH, IPF1, ISL1, PAX6, TBX1, SOX1, and SOX17).
|
25287138 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No other significant associations between different tumor parameters examined and SOX17 methylation status were observed.
|
23403728 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The vascular effects of Sox17 persisted throughout tumor growth.
|
23241958 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, SOX17 negatively regulates canonical WNT/β-catenin signaling pathway and inhibits human HCC cells growth, providing an explanation for the loss of expression by epigenetic mechanisms in these tumors.
|
20716954 |
2011 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Sox17 methylation was also associated with tumor stage (P = 0.028) and lymph node metastasis (P = 0.013).
|
19301122 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sox17 plays a tumor suppressor role through suppression of Wnt signaling.
|
19549530 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Sox17, which is expressed in the normal gut epithelium but exhibits reduced expression in intestinal neoplasia, is antagonistic to Wnt signaling.
|
17875931 |
2007 |