SOX17, SRY-box transcription factor 17, 64321

N. diseases: 113; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.060 Biomarker phenotype BEFREE The SOX17 (SRY-related HMG-box) transcription factor is involved in a variety of biological processes and is related to the tumorigenesis and progression of multiple tumors. 25971583 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.060 Biomarker phenotype BEFREE Loss of SOX17 removes the normal inhibition of WNT signaling and promotes esophageal tumorigenesis. 22921431 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.060 Biomarker phenotype BEFREE Therefore, the aim of this study was to elucidate the vital role of Sox17 in the tumorigenesis and progression of gastric cancer. 21514720 2011
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.060 Biomarker phenotype BEFREE Sox17 may be a valuable biomarker for the study of breast cancer carcinogenesis and progression. 19301122 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.060 Biomarker phenotype BEFREE The roles of Sox17 in gastric tumorigenesis were examined by cell culture experiments and by construction of Sox17 transgenic mice. 19549530 2009
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.060 PosttranslationalModification phenotype BEFREE Together, our studies suggest that SOX17 is a negative modulator of canonical Wnt signaling, and that SOX17 silencing due to promoter hypermethylation is an early event during tumorigenesis and may contribute to aberrant activation of Wnt signaling in CRC. 18413743 2008