VESICOURETERAL REFLUX 3
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract.
|
20960469 |
2010 |
VESICOURETERAL REFLUX 3
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract.
|
20960469 |
2010 |
VESICOURETERAL REFLUX 3
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract.
|
20960469 |
2010 |
VESICOURETERAL REFLUX 3
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
VESICOURETERAL REFLUX 3
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Vesico-Ureteral Reflux
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
We have identified mutations in SOX17, an HMG-box transcription factor and Wnt signaling antagonist, in eight patients with CAKUT (seven vesico-ureteric reflux, one pelvic obstruction).
|
20960469 |
2010 |
Vesico-Ureteral Reflux
|
0.410 |
Biomarker
|
disease |
CTD_human |
|
|
|
Vesico-Ureteral Reflux
|
0.410 |
Biomarker
|
disease |
HPO |
|
|
|
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
SRY-box containing gene 17 (SOX17) was reported to be indispensable for embryonic development and a candidate tumor suppressor gene which antagonizes the canonical WNT/β-catenin signaling pathway in colorectal cancer.
|
20716954 |
2011 |
Colorectal Carcinoma
|
0.320 |
PosttranslationalModification
|
disease |
BEFREE |
Together, our studies suggest that SOX17 is a negative modulator of canonical Wnt signaling, and that SOX17 silencing due to promoter hypermethylation is an early event during tumorigenesis and may contribute to aberrant activation of Wnt signaling in CRC.
|
18413743 |
2008 |
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Together, our studies suggest that SOX17 is a negative modulator of canonical Wnt signaling, and that SOX17 silencing due to promoter hypermethylation is an early event during tumorigenesis and may contribute to aberrant activation of Wnt signaling in CRC.
|
18413743 |
2008 |
Colorectal Neoplasms
|
0.310 |
AlteredExpression
|
group |
LHGDN |
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.
|
18413743 |
2008 |
Colorectal Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.
|
18413743 |
2008 |
Familial primary pulmonary hypertension
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
SOX17 Mutations in Japanese Patients with Pulmonary Arterial Hypertension.
|
30044643 |
2018 |
2-oxo-hept-3-ene-1,7-dioate hydratase activity
|
0.300 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
SOX17 Mutations in Japanese Patients with Pulmonary Arterial Hypertension.
|
30044643 |
2018 |
Teratogenesis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Decreased nuclear SOX17 in the hPST model was strongly correlated with in vivo teratogenicity.
|
24154490 |
2014 |
Familial vesicoureteral reflux
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract.
|
20960469 |
2010 |
Vesicoureteral Reflux 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Cholangiocarcinoma
|
0.210 |
Biomarker
|
disease |
BEFREE |
SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma.
|
28237397 |
2017 |
Cholangiocarcinoma
|
0.210 |
ModifyingMutation
|
disease |
RGD |
Genes identified as being commonly overexpressed in parent BDEneu cells, tumors, and in a BDEneu tumor-derived cholangiocarcinoma cell line included Sox17, Krt20, Erbb2, and Sphk1 when respectively compared to BDEsp cells, tumors, and tumor-derived BDEsp cholangiocarcinoma cells.
|
20816680 |
2010 |
Biliary Atresia
|
0.200 |
Biomarker
|
disease |
MGD |
Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.
|
28432216 |
2017 |
Biliary Atresia
|
0.200 |
Biomarker
|
disease |
MGD |
Our results suggest that Sox17 plays a dosage-dependent function in the morphogenesis and maturation of gallbladder and bile duct epithelia during the late-organogenic stages, highlighting a novel entry point to the understanding of the etiology and pathogenesis of human congenital biliary atresia.
|
23293295 |
2013 |
Adult Cholangiocarcinoma
|
0.200 |
ModifyingMutation
|
disease |
RGD |
Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.
|
20816680 |
2010 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we review the roles of SOX17 in cancer and discuss its cross-talk with the WNT/β-catenin pathway, potentially reconciling its activity as re-engineered reprogramming factor and mutated cancer driver gene.
|
31419525 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The SoxF family (SOX7, SOX17, SOX18) plays an important role in angio- and lymphangiogenesis, with SOX18 seemingly being an attractive target for anti-angiogenic therapy and the treatment of metastatic disease in cancer.
|
30914279 |
2019 |