|
Spinal Muscular Atrophy
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1.
|
14520560 |
2003 |
|
Tauopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results implicate the human tau gene as a target gene for the alternative splicing regulator Tra2 beta, suggesting that Tra2 beta may play a role in aberrant tau exon 10 alternative splicing and in the pathogenesis of tauopathies.
|
12649279 |
2003 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, our results indicate that reduced expression of SFRS10, as observed in tissues from obese humans, alters LPIN1 splicing, induces lipogenesis, and therefore contributes to metabolic phenotypes associated with obesity.
|
21803291 |
2011 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Tra2β were preferentially expressed in proliferative compartment of normal human colonic glands and adenocarcinomas, where Ets1 and heat shock factor 1 were also highly expressed.
|
23361474 |
2013 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tra2β knockdown caused apoptosis of HCT116 cells.
|
23361474 |
2013 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, SFRS10 was not detected in normal human retina but was observed as distinct nuclear speckles in AMD retinae.
|
24098751 |
2013 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tra2β knockdown caused apoptosis of HCT116 cells.
|
23361474 |
2013 |
|
Progressive supranuclear palsy
|
0.300 |
Biomarker
|
disease |
CTD_human |
We also found SRSF2, as well as another tau splicing factor, TRA2B, to be increased in brains of PSP patients.
|
25402454 |
2014 |
|
Ophthalmoplegia, Progressive Supranuclear
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial complex 1 inhibition increases 4-repeat isoform tau by SRSF2 upregulation.
|
25402454 |
2014 |
|
Supranuclear Palsy, Progressive, 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial complex 1 inhibition increases 4-repeat isoform tau by SRSF2 upregulation.
|
25402454 |
2014 |
|
Age at menarche
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
|
25231870 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
It demonstrated that Tra2β was expressed higher in NSCLC tumor tissues compared with adjacent non-tumor tissues.
|
24952301 |
2014 |
|
Hepatitis, Alcoholic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also measured messenger RNA levels of SIRT1, SFRS10, and lipin-1β and lipin-1α in liver samples from patients with alcoholic hepatitis and individuals without alcoholic hepatitis (controls).
|
24262277 |
2014 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results indicated that Tra2β was involved in the tumorigenesis of NSCLC and might be a potential therapeutic target of NSCLC.
|
24952301 |
2014 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
response to bronchodilator
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We proposed here a hypothetic model to illustrate that impaired glucose metabolism in AD brain may increase the expression of splicing protein hnRNP A1 and reduce Tra2β-1, which cause the imbalanced expression of mRAGE and esRAGE.
|
25689357 |
2015 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To analyze the expression levels of TRA2β protein in glioma tissues, we performed immunohistochemical and Western blot analysis on human glioma tissues.
|
26298634 |
2015 |
|
Squamous cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings improve our current knowledge of oncogenic drivers in lung SCC and provide a potential therapeutic strategy for lung SCC patients with TRA2B-DNAH5 fusion.
|
27670699 |
2016 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
TRA2B is associated with cancer cell survival and therapeutic sensitivity.
|
28416606 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The splicing regulators Sam68 and Tra2β increase expression in prostate cancer.
|
28382513 |
2017 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The splicing regulators Sam68 and Tra2β increase expression in prostate cancer.
|
28382513 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
TRA2B is associated with cancer cell survival and therapeutic sensitivity.
|
28416606 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overall, these findings suggest that the downregulation of miR-335 in A459 lung cancer cells promoted cell proliferation through upregulation of Tra2β, mediated via activation of the AKT/mTOR signaling pathway, and suggest that miR-335 may have potential as a novel therapeutic target for NSCLC.
|
29161765 |
2018 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we demonstrate that miR-335 expression is reduced in non-small cell lung cancer (NSCLC) tumors relative to non-cancerous adjacent tissues, while the expression of Tra2β is increased.
|
29161765 |
2018 |