Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We proposed here a hypothetic model to illustrate that impaired glucose metabolism in AD brain may increase the expression of splicing protein hnRNP A1 and reduce Tra2β-1, which cause the imbalanced expression of mRAGE and esRAGE.
|
25689357 |
2015 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, we demonstrate that TRA2β is regulated by the MYC oncogene, plays a role in metastasis maintenance in vivo, and its levels correlate with breast cancer patient survival.
|
31775037 |
2019 |
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To analyze the expression levels of TRA2β protein in glioma tissues, we performed immunohistochemical and Western blot analysis on human glioma tissues.
|
26298634 |
2015 |
Hepatitis, Alcoholic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also measured messenger RNA levels of SIRT1, SFRS10, and lipin-1β and lipin-1α in liver samples from patients with alcoholic hepatitis and individuals without alcoholic hepatitis (controls).
|
24262277 |
2014 |
Spinal Muscular Atrophy
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1.
|
14520560 |
2003 |
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we demonstrate that miR-335 expression is reduced in non-small cell lung cancer (NSCLC) tumors relative to non-cancerous adjacent tissues, while the expression of Tra2β is increased.
|
29161765 |
2018 |
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, our results indicate that reduced expression of SFRS10, as observed in tissues from obese humans, alters LPIN1 splicing, induces lipogenesis, and therefore contributes to metabolic phenotypes associated with obesity.
|
21803291 |
2011 |
Laryngeal Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reverse-transcription quantitative polymerase chain reaction analysis and immunochemistry analysis indicated that the increased expression of Tra2β in LSCC was significantly associated with poor differentiation, lymph node metastasis, and advanced clinical stage.
|
30597574 |
2019 |
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The splicing regulators Sam68 and Tra2β increase expression in prostate cancer.
|
28382513 |
2017 |
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The splicing regulators Sam68 and Tra2β increase expression in prostate cancer.
|
28382513 |
2017 |
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, we demonstrate that TRA2β is regulated by the MYC oncogene, plays a role in metastasis maintenance in vivo, and its levels correlate with breast cancer patient survival.
|
31775037 |
2019 |