Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
SP-B pre-proteins might serve as a biomarker in pulmonary diseases with alveolar or interstitial damage such as ILDs, especially in IPF.
|
29763900 |
2018 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Previous studies have indicated that a SP-B 1580C/T polymorphism (SNP rs1130866) was associated with lung diseases including pneumonia.
|
26620227 |
2016 |
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Mutations of genes affecting surfactant homeostasis, such as SFTPB, SFTPC and ABCA3, lead to diffuse lung disease in neonates and children.
|
21867529 |
2011 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Individuals heterozygous for this mutation have partial absence of surfactant protein-B and could be at risk of lung disease when exposed to additional risk factors for impaired surfactant function such as tobacco smoking.
|
19833825 |
2010 |
Lung diseases
|
0.600 |
Biomarker
|
group |
RGD |
[Expression of HoxB5 mRNA and their effect on lung development in premature rats with hyperoxia-induced chronic lung disease].
|
19099817 |
2008 |
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
In this study we tested whether SP-B was in association with two further pulmonary diseases in children, i. e. severe infections caused by respiratory syncytial virus and bronchial asthma.
|
17498296 |
2007 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The genes encoding SP-B (SFTPB), SP-C (SFTPC), and ABCA3 (ABCA3) were sequenced from the parents of one infant and two unrelated infants with fatal neonatal lung disease.
|
17429902 |
2007 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Pulmonary surfactant is essential to maintain alveolar patency, and invariably fatal neonatal lung disease has been recognized to involve mutations in the genes encoding surfactant protein-B or ATP-binding cassette transporter family member ABCA3.
|
17660803 |
2007 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Differences in amounts of SP-B resulting from the promoter SNP could affect the clinical presentation of pulmonary disease.
|
17071721 |
2007 |
Lung diseases
|
0.600 |
Biomarker
|
group |
CTD_human |
Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen.
|
16863852 |
2006 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The results indicate that intron 4 length variants affect SP-B mRNA splicing, and that this may contribute to lung disease.
|
15790313 |
2005 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
LHGDN |
The results indicate that intron 4 length variants affect SP-B mRNA splicing, and that this may contribute to lung disease.
|
15790313 |
2005 |
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis of surfactant protein expression in three patients revealed a specific staining pattern for surfactant protein-B, which was the same pattern observed in several infants with fatal lung disease due to ABCA3 mutations.
|
15976379 |
2005 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Surfactant Protein B (SP-B) deficiency has been recently identified as an uncommon, autosomal recessive lung disorder in term infants.
|
15027668 |
2004 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
LHGDN |
This work reviews the current state of knowledge concerning the lung diseases associated with mutations in the SP-B and SP-C genes, and the potential roles of abnormal SP-B and SP-C expression and genetic variation in these genes in other lung diseases.
|
14977415 |
2004 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This work reviews the current state of knowledge concerning the lung diseases associated with mutations in the SP-B and SP-C genes, and the potential roles of abnormal SP-B and SP-C expression and genetic variation in these genes in other lung diseases.
|
14977415 |
2004 |
Lung diseases
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In a number of inflammatory diseases of the lung, elevated nitric oxide (NO) levels are associated with decreased SP-B levels, suggesting that reduced SP-B levels contribute to lung injury.
|
12896877 |
2003 |
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
The population frequency of five known and four novel SNPs was studied, providing as many potential markers for pulmonary disease related to SFTPB.
|
12784301 |
2003 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The SP-B SNP B1580_C (odds ratio:7.63; confidence interval:1.64-35.4; P</=0.01), to be a risk factor for IPF smokers, has also been shown to be a risk factor for other pulmonary diseases.
|
13680361 |
2003 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Allelic variations of the SP-A and SP-B genes have been shown to be important genetic determinants in individual susceptibility to RDS, which is a good general model for a multifactorial pulmonary disease resulting from complex interactions between several environmental and genetic factors.
|
12452477 |
2002 |
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
SP-B deficiency or dysfunction may be more common than once thought and may play a significant role in neonatal lung disease.
|
11202476 |
2001 |
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
The development of peptide analogues of SP-B and SP-C offers the possibility to study their molecular mechanism of action and will allow the design of surfactant formulations for specific pulmonary diseases and better quality control.
|
11001826 |
2000 |
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
We conclude that a novel splicing mutation was the cause of lung disease in these children and that hereditary SP-B deficiency can be the cause of lung disease in older children.
|
10960490 |
2000 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Hereditary surfactant protein B (SP-B) deficiency is an uncommon autosomal recessive lung disorder that causes hypoxemic respiratory failure in mature, morphologically normal infants.
|
11041444 |
2000 |
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency.
|
10571948 |
1999 |