Respiratory Distress Syndrome, Adult
|
0.100 |
Biomarker
|
disease |
BEFREE |
A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome.
|
28465315 |
2017 |
Respiratory Distress Syndrome, Adult
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHF5633 is a new generation synthetic surfactant containing both SP-B and SP-C analogues developed for the treatment of respiratory distress syndrome.
|
27973472 |
2017 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genotyping studies demonstrate a significant association between human SP-B genetic variants and ARDS.
|
26863117 |
2016 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There is a possible involvement of SP-A2 and SP-B genes polymorphisms in the genetic predisposition to respiratory distress syndrome.
|
26061924 |
2015 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome.
|
21180884 |
2011 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In multivariate analysis, the presence of variable nuclear tandem repeat surfactant protein B gene polymorphism was associated with a 3.51 greater odds of death at 60 days in patients with acute respiratory distress syndrome as compared to those patients with the wild-type genotype (95% confidence interval 1.39-8.88, p = 0.008).
|
18679120 |
2008 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In multivariate analysis, the presence of variable nuclear tandem repeat surfactant protein B gene polymorphism was associated with a 3.51 greater odds of death at 60 days in patients with acute respiratory distress syndrome as compared to those patients with the wild-type genotype (95% confidence interval 1.39-8.88, p = 0.008).
|
18679120 |
2008 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of surfactant protein B polymorphisms of healthy term newborns with preterm newborns having respiratory distress syndrome.
|
17581675 |
2007 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data provide evidence that ABCA3 mutations are associated not only with a deficiency of ABCA3 but also with an abnormal processing and routing of SP-B and SP-C, leading to severe alterations of surfactant homeostasis and respiratory distress syndrome.
|
16728712 |
2006 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of surfactant protein B (SP-B) have been associated with respiratory distress syndrome (RDS) in the prematurely born infant.
|
16549540 |
2006 |
Respiratory Distress Syndrome, Adult
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surfaxin (lucinactant), a peptide-based surfactant consisting of dipalmitoylphosphatidylcholine (DPPC) plus KL(4) (sinapultide) (a synthetic peptide modeled after human surfactant protein-B), is effective in treating respiratory distress syndrome in preterm infants.
|
15633204 |
2005 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective was to determine whether the SP-B + 1580 CC genotype is associated with an increased risk of respiratory failure and ARDS in adults with community-acquired pneumonia.
|
15190959 |
2004 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Surfactant protein B polymorphism and respiratory distress syndrome in premature twins.
|
12483294 |
2003 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific alleles of the SP-A and SP-B genes associate interactively with susceptibility to respiratory distress syndrome.
|
12667827 |
2003 |
Respiratory Distress Syndrome, Adult
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that SP-B or a linked gene contributes to susceptibility to ARDS.
|
11076040 |
2000 |
Respiratory Distress Syndrome, Adult
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surfactant replacement therapy with bovine and porcine lung surfactant extracts, which contain only polar lipids and SP-B and SP-C, has revolutionized the clinical management of premature infants with respiratory distress syndrome.
|
11001826 |
2000 |
Respiratory Distress Syndrome, Adult
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B.
|
9475280 |
1998 |
Respiratory Distress Syndrome, Adult
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dinucleotide repeats in the human surfactant protein-B gene and respiratory-distress syndrome.
|
7832777 |
1995 |