|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
By balancing these features in one mimic, a novel analogue was created that emulates SP-C's in vitro surface activity while overcoming many of the challenges related to natural SP-C. Peptoid-based analogues hold great potential for use in a synthetic, biomimetic LS formulation for treating RDS.
|
30972750 |
2019 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently the first synthetic surfactant that contains analogues of the two hydrophobic surfactant proteins B (SP-B) and SP-C entered clinical trials for the treatment of neonatal RDS.
|
30357986 |
2019 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
CHF5633 is a new generation synthetic surfactant containing both SP-B and SP-C analogues developed for the treatment of respiratory distress syndrome.
|
27973472 |
2017 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome.
|
28465315 |
2017 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of association of SFTPC rs1124 polymorphism with RDS development in Iranian newborns.
|
27884070 |
2017 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
Though natural surfactants (SF) are clinically superior to protein-free synthetic preparations, CHF-5633, a synthetic SF containing SP-B and SP-C analog peptides is a potential alternative to natural SF for treating neonatal respiratory distress syndrome (RDS).
|
28221717 |
2017 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We previously identified the c.435G>C variant in the SFTPC gene associated with fatal neonatal respiratory distress syndrome in an infant girl.
|
28295039 |
2017 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Surfactant protein C mutations are dominant or sporadic disorders leading to a broad spectrum of manifestations from neonatal respiratory distress syndrome to adult pulmonary fibrosis.
|
24047351 |
2013 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus our results suggest SP-C and Ki67 may have participated in the pulmonary pathological process in ventilated/oxygen treated preterm infants with RDS, and exogenous surfactant had no effect on the expression of SP-C and Ki67 in the lungs of ventilated/oxygen treated preterm infants with RDS.
|
23027351 |
2012 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
The BRICHOS domain was initially defined from sequence alignments of the Bri protein associated with familial dementia, chondromodulin associated with chondrosarcoma and surfactant protein C precursor (proSP-C) associated with respiratory distress syndrome and interstitial lung disease (ILD).
|
21668643 |
2011 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
This combined statistical, in vitro, and in silico approach suggests that reduced SFTPC transcription contributes to the genetic risk for neonatal RDS in developmentally susceptible infants.
|
20539253 |
2010 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the common mutations in the surfactant protein-B (121ins2), surfactant protein-C (I73T), and ATP-binding cassette member A3 (E292V) genes in population-based or case-control cohorts of newborn respiratory distress syndrome (RDS) is unknown.
|
18317237 |
2008 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
The allelic variants of the genes encoding the surfactant proteins (SP) SP-A1, SP-A2, SP-B, and SP-C have been associated with RDS.
|
17127271 |
2007 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
The common allelic variants of SP-A1, SP-A2, SP-B, SP-C, and SP-D genes are associated with respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), or respiratory syncytial virus (RSV) bronchiolitis.
|
17142161 |
2006 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data provide evidence that ABCA3 mutations are associated not only with a deficiency of ABCA3 but also with an abnormal processing and routing of SP-B and SP-C, leading to severe alterations of surfactant homeostasis and respiratory distress syndrome.
|
16728712 |
2006 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, the exonic variation of the SP-C gene in the Finnish population (n=472) was defined, and the association of the allelic variants with the susceptibility to RDS and BPD was examined.
|
14735158 |
2004 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
These include BRI(2), which is related to familial British and Danish dementia (FBD and FDD); Chondromodulin-I (ChM-I), related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress syndrome (RDS).
|
12114016 |
2002 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
Biomarker
|
disease |
BEFREE |
Surfactant replacement therapy with bovine and porcine lung surfactant extracts, which contain only polar lipids and SP-B and SP-C, has revolutionized the clinical management of premature infants with respiratory distress syndrome.
|
11001826 |
2000 |
|
Respiratory Distress Syndrome, Newborn
|
0.400 |
SusceptibilityMutation
|
disease |
ORPHANET |
|
|
|