SHBG, sex hormone binding globulin, 6462

N. diseases: 368; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.510 Biomarker disease CTD_human Alcoholic hypogonadism: hormonal response to clomiphene. 8590623 1996
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.510 Biomarker disease PSYGENET Sex hormone binding globulin phenotypes: their detection and distribution in healthy adults and in different clinical conditions. 8088001 1994
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.510 Biomarker disease BEFREE Plasma sex-related hormones (estradiol, estrone, total testosterone, progesterone, follicle stimulated hormone [FSH], luteinizing hormone), and sex hormone binding globulin were measured by mass spectrometry or automated immunoassays from 44 recently-abstained subjects (29 males and 15 females; mean age = 45.9 ± 15.6) meeting DSM-IV-TR criteria for AD and 44 age-, sex- and race-matched non-AD controls. 30840924 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE The available evidence supports treatment in people with type 2 diabetes and SBP more than 140 mmHg, using any of the major antihypertensive drug classes. 27870655 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE Measurements of SHBG are widely used to predict plasma free testosterone levels in patients suffering from excess androgen exposures, but have broader utility in assessing the risk for endocrine diseases and clinical sequelae of the metabolic syndrome, namely, type 2 diabetes and cardiovascular disease. 22531107 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE We found a reduced risk of impaired glucose regulation (IGR) and T2DM in male smokers with normal weight (body mass index (BMI) < 25 kg/m<sup>2</sup> or waist circumference (WC) < 90 cm) compared with nonsmokers after adjusting for age, alcohol intake, physical activity, educational level, family history of diabetes, SBP, DBP, TG, TC, HDL-C, and LDL-C. 31612146 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Multivariate linear regression models were used to assess the impact of race (white, black, and other) and family history of type 2 diabetes on body mass index, waist circumference, and waist to hip ratio; glycemic measures (glucose and insulin levels obtained during a standard 75-g oral glucose tolerance test, fasting glucose to insulin ratio, and homeostasis model assessment model of insulin resistance derived from fasting levels of glucose and insulin), hemoglobin A(1c), and SHBG, and dehydroepiandrosterone sulfate levels. 15507516 2005
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE BMI = body mass index; DPP-4 = dipeptidyl peptidase-4; DXA = dual energy X-ray absorptiometry; GIP = glucose-dependent insulinotropic peptide; GLP-1 = glucagon-like peptide-1; HOMA-B = homeostasis model assessment for beta-cell function; HOMA-IR = homeostasis model assessment of insulin resistance; IAI = insulin action index; IGT = impaired glucose tolerance; IR = insulin resistance; MBCI = modified beta-cell function index; OGTT = oral glucose tolerance test; QUICKI = quantitative insulin sensitivity check index; PCOS = polycystic ovary syndrome; SHBG = sex hormone-binding globulin; T2D = type 2 diabetes. 29144805 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Taken together, these data provide support for an expanded role of SHBG in the pathophysiology of insulin resistance and T2DM. 22047952 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Significant additive interactions with obesity or central obesity were detected for total testosterone (RERI=2.75, 95% CI=0.92,4.59), SHBG (RERI=5.71, 95% CI=0.77,10.64), and FEI (RERI=-9.96, 95% CI=-19.18,-0.74) with regard to IR, beta-cell dysfunction, and T2D. 27914732 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE Lower levels of sex hormone-binding globulin increase risks of MetS and T2DM in both sexes. 29241756 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE NAFLD might be an important influencing factor for the association of circulating SHBG with MS in T2D patients. 29109457 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Polymorphisms of the <i>SHBG</i> gene linked to low SHBG protein levels also strongly predicted increased risk of type 2 diabetes, thus raising the possibility that SHBG may play a role in the pathogenesis of insulin resistance and diabetes. 29141991 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE The aim of the present study was to investigate the association of SHBG in relation to MetS components among men with type 2 diabetes (T2D). 29245159 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE To compare achievement of quality goals (HbA1c, weight loss/body mass index [BMI], systolic blood pressure [SBP]), including maintaining HbA1c, between patients with type 2 diabetes mellitus (T2DM) treated with canagliflozin 300 mg (CANA) or a GLP-1 in an actual practice setting. 29557199 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Low plasma sex hormone-binding globulin (SHBG) levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk. 26441241 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE These findings provide a potential mechanism to explain why low SHBG predicts the development of type 2 diabetes. 25226295 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Consumption of high coffee and caffeine is associated with a reduced risk of low SHBG, an established risk marker for T2DM, which might contribute to the protective effects of coffee for type 2 diabetes. 28664630 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE The correlation between SHBG and insulin resistance that is evident in a number of cross-sectional studies is in keeping with the suggestion that the association between SHBG and incidence of type 2 DM is explained by insulin resistance. 23121642 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE This mechanism provides a biological explanation for why SHBG is a sensitive biomarker of insulin resistance and the metabolic syndrome, and why low plasma SHBG levels are a risk factor for developing hyperglycemia and type 2 diabetes, especially in women. 19786070 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE There is no consensus as to the optimal SBP target for patients with T2DM, though data suggest a benefit to targeting SBP < 130 mmHg in patients with less-intensive glucose control. 31760494 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Menstrual dysfunction is common in girls with recently diagnosed type 2 diabetes and associated with alterations in sex steroids, SHBG, and AST but not with alteration in insulin sensitivity or β-cell function and did not improve with 2 years of antihyperglycemic treatment. 29697830 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE In light of studies investigating polymorphisms in SHBG and T2DM, our group and others have hypothesized that SHBG may represent a candidate gene for PCOS. 21178921 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE SHBG and TE are independent risk factors for the development of T2D in women. 28223343 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease CTD_human Polymorphisms in the SHBG gene are associated with risk of type 2 diabetes, but few studies have addressed SHBG as a predictor of CV events. 21982312 2011