SHBG, sex hormone binding globulin, 6462

N. diseases: 368; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE Free E2 and SHBG were also measured in the serum of (e) postmenopausal patients having breast cancer (n = 38) and (f) matched control cancer patients (n = 67). 4038881 1985
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker disease BEFREE Free E2 and SHBG were also measured in the serum of (e) postmenopausal patients having breast cancer (n = 38) and (f) matched control cancer patients (n = 67). 4038881 1985
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.080 Biomarker group BEFREE Free E2 and SHBG were also measured in the serum of (e) postmenopausal patients having breast cancer (n = 38) and (f) matched control cancer patients (n = 67). 4038881 1985
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 Biomarker group BEFREE Free E2 and SHBG were also measured in the serum of (e) postmenopausal patients having breast cancer (n = 38) and (f) matched control cancer patients (n = 67). 4038881 1985
CUI: C0016034
Disease: Breast Fibrocystic Disease
Breast Fibrocystic Disease
0.010 GeneticVariation disease BEFREE Therefore, we found no difference in free E2 percentage, calculated free E2 concentration or SHBG between premenopausal women at risk, women with benign breast disease, patients cured for early breast cancer or having breast cancer and matched controls. 4038881 1985
CUI: C0079588
Disease: Ichthyosis, X-Linked
Ichthyosis, X-Linked
0.010 AlteredExpression disease BEFREE Serum levels of sex hormone binding globulin (SHBG), testosterone, free testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone sulphate, oestradiol, oestrone, oestrone sulphate, FSH, and LH were measured in 20 steroid sulphatase-deficient men with recessive X-linked ichthyosis and in normal men. 3864567 1985
Placental Steroid Sulfatase Deficiency
0.010 AlteredExpression disease BEFREE Serum levels of sex hormone binding globulin (SHBG), testosterone, free testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone sulphate, oestradiol, oestrone, oestrone sulphate, FSH, and LH were measured in 20 steroid sulphatase-deficient men with recessive X-linked ichthyosis and in normal men. 3864567 1985
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.040 AlteredExpression disease BEFREE Sex hormone-binding globulin (SHBG) levels in serum are affected by thyroid status; hyperthyroidism is associated with high SHBG levels, whereas hypothyroid patients have low or normal SHBG levels. 3084540 1986
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism
0.030 AlteredExpression disease BEFREE Sex hormone-binding globulin (SHBG) levels in serum are affected by thyroid status; hyperthyroidism is associated with high SHBG levels, whereas hypothyroid patients have low or normal SHBG levels. 3084540 1986
Generalized Thyroid Hormone Resistance
0.020 Biomarker disease BEFREE This study was undertaken to test the usefulness of SHBG determinations to define the thyroid status in two hyperthyroxinemic states: thyroid hormone resistance (THR) and familial dysalbuminemic hyperthyroxinemia (FDH). 3084540 1986
Hyperthyroxinemia, Familial Dysalbuminemic
0.010 Biomarker disease BEFREE This study was undertaken to test the usefulness of SHBG determinations to define the thyroid status in two hyperthyroxinemic states: thyroid hormone resistance (THR) and familial dysalbuminemic hyperthyroxinemia (FDH). 3084540 1986
CUI: C2940786
Disease: Thyroid Hormone Resistance Syndrome
Thyroid Hormone Resistance Syndrome
0.010 Biomarker disease BEFREE This study was undertaken to test the usefulness of SHBG determinations to define the thyroid status in two hyperthyroxinemic states: thyroid hormone resistance (THR) and familial dysalbuminemic hyperthyroxinemia (FDH). 3084540 1986
CUI: C0342513
Disease: Idiopathic hirsutism
Idiopathic hirsutism
0.020 Biomarker phenotype BEFREE Lack of correlation between sex hormone binding globulin and free testosterone in some cases of "idiopathic" hirsutism. 3598079 1987
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.040 Biomarker disease BEFREE Sex hormone-binding globulin was increased in zero of 13 affected patients (versus 19 of 20 hyperthyroid, chi 2:p less than 0.001); ferritin was elevated in two of 13 patients (versus 11 of 20 hyperthyroid, p less than 0.02); angiotensin converting enzyme activity was increased in one of 13 patients (versus 12 of 20 hyperthyroid, p less than 0.025). 2919610 1989
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker disease BEFREE Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma. 1958578 1991
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.040 Biomarker disease BEFREE Dehydroepiandrosterone sulfate (DHEAS), testosterone, androstenedione, 17-beta estradiol and sex hormone binding globulin have been assayed in 50 HLA-identical postmenopausal rheumatoid arthritis (RA) discordant sibling pairs. 1491383 1992
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.510 Biomarker disease PSYGENET Sex hormone binding globulin phenotypes: their detection and distribution in healthy adults and in different clinical conditions. 8088001 1994
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 Biomarker disease BEFREE We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2. 8130892 1994
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism
0.040 Biomarker disease BEFREE The effects of T3 on these genes are consistent with the increase in circulating SHBG and decrease in circulating CBG observed in hyperthyroidism. 8130892 1994
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 Biomarker group BEFREE We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2. 8130892 1994
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
0.100 GeneticVariation disease BEFREE There was no relationship between the presence of the variant LH and the clinical and hormonal parameter in the PCOS subjects; however, in the controls the presence of the variant LH was associated with a higher serum total testosterone (P = 0.046), oestradiol (P = 0.03) and SHBG (P = 0.002). 7586598 1995
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.080 AlteredExpression disease BEFREE Further, it indicates that endometrial cancer cell synthesis of SHBG mRNA is lost as these cells undergo de-differentiation. 7779755 1995
Malignant neoplasm of urinary bladder
0.060 GeneticVariation disease BEFREE Thus, our results suggest that GSTM1 is involved in the detoxification of 3- and 4-ABP and may contribute to the racial variation in bladder cancer incidence among white, black, and Asian males in Los Angeles, CA. 8634658 1995
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.060 GeneticVariation disease BEFREE Thus, our results suggest that GSTM1 is involved in the detoxification of 3- and 4-ABP and may contribute to the racial variation in bladder cancer incidence among white, black, and Asian males in Los Angeles, CA. 8634658 1995
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.060 AlteredExpression disease BEFREE Further, it indicates that endometrial cancer cell synthesis of SHBG mRNA is lost as these cells undergo de-differentiation. 7779755 1995