Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates. 26050255 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Low plasma sex hormone-binding globulin (SHBG) levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk. 26441241 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE These findings provide a potential mechanism to explain why low SHBG predicts the development of type 2 diabetes. 25226295 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Single-nucleotide polymorphisms in the SHBG gene influence circulating SHBG levels in American patients with PCOS and may predict the development of type 2 diabetes. 23001781 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease CTD_human Polymorphisms in the SHBG gene are associated with risk of type 2 diabetes, but few studies have addressed SHBG as a predictor of CV events. 21982312 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE The correlation between SHBG and insulin resistance that is evident in a number of cross-sectional studies is in keeping with the suggestion that the association between SHBG and incidence of type 2 DM is explained by insulin resistance. 23121642 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE Measurements of SHBG are widely used to predict plasma free testosterone levels in patients suffering from excess androgen exposures, but have broader utility in assessing the risk for endocrine diseases and clinical sequelae of the metabolic syndrome, namely, type 2 diabetes and cardiovascular disease. 22531107 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Sex hormone-binding globulin and type 2 diabetes mellitus. 22047952 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Sex hormone-binding globulin genetic variation: associations with type 2 diabetes mellitus and polycystic ovary syndrome. 21178921 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Although SHBG SNPs associated with type 2 diabetes mellitus do not appear to be associated with PCOS status, rs1799941 and rs727428 genotypes are associated with SHBG levels independent of the effects of insulin resistance and obesity. 21252242 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE This mechanism provides a biological explanation for why SHBG is a sensitive biomarker of insulin resistance and the metabolic syndrome, and why low plasma SHBG levels are a risk factor for developing hyperglycemia and type 2 diabetes, especially in women. 19786070 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Possible mechanisms by which high circulating SHBG prevents the development of type 2 diabetes involve regulation of fasting glycemia but not alteration of insulin secretory function. 20841609 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE However, the AA genotype of SNP rs1800624 (-374T/A) was consistently associated with lower SBP [-5.0 mmHg (95% confidence interval -10.4 to 0.3)] and DBP [-4.2 (-7.2 to -1.3)], pulse pressure [-0.8 (-5.0 to 3.4)] as well as with less arterial stiffness [-0.56 SD (-1.04 to -0.09)] in individuals with normal glucose metabolism, but with higher SBP [6.2 (0.9-11.5)], DBP [2.1 (-0.7 to 5.0)] and pulse pressure [4.1 (-0.2 to 8.4)] in individuals with impaired glucose metabolism or type 2 diabetes mellitus (P for interaction <or=0.05 in all analyses). 20051912 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. 19933169 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Sex hormone-binding globulin and risk of type 2 diabetes in women and men. 19657112 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Further analysis with adjustment for age, BMI, SBP, DBP, CHO and TG demonstrated that this SNP was strongly associated with T2D (P = 0.013, OR = 2.287). 16572495 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Multivariate linear regression models were used to assess the impact of race (white, black, and other) and family history of type 2 diabetes on body mass index, waist circumference, and waist to hip ratio; glycemic measures (glucose and insulin levels obtained during a standard 75-g oral glucose tolerance test, fasting glucose to insulin ratio, and homeostasis model assessment model of insulin resistance derived from fasting levels of glucose and insulin), hemoglobin A(1c), and SHBG, and dehydroepiandrosterone sulfate levels. 15507516 2005
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Therefore, low SHBG could be a useful tool for identifying presymptomatic individuals with diabetes mellitus type 2 including those with androgen disorders. 11117669 2001