|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Population mean levels show a mild total T decline, an SHBG increase, a steeper free T decline, and a moderate LH increase with important contribution of comorbidities (e.g., obesity) to these changes.
|
30888401 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a multivariate logistic regression analysis, lower peak SBP [odds ratio (OR) 1.02;95% confidence interval (CI) 1.00-1.04, P = 0.017] and rapid early rise in heart rate (OR 15.03; 95% CI 6.23-36.24, P < 0.001) were associated with a higher risk of revealed symptoms while the use of antihypertensive treatment was associated with a lower risk of revealed symptoms (OR 0.40; 95% CI 0.18-0.89, P = 0.025), independent of age, obesity, LV ejection fraction and aortic valve area.
|
31157741 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both boys and girls with obesity had lower sex hormone-binding globulin (SHBG; P < 0.0001) than NW.
|
30985874 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Men with obesity often present with low testosterone (T) and sex hormone-binding globulin (SHBG) levels.
|
31274482 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We tested the effects of weight loss on serum estradiol, estrone, testosterone, and sex hormone-binding globulin (SHBG) in overweight/obese women 18 months after completing a year-long, 4-arm, randomized-controlled dietary weight loss and/or exercise trial.
|
30461557 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sex hormone binding globulin levels were lowest in OB-g and lower in PCOS-d than in NW-g (PCOS-d vs NW-g, P = 0.005; OB-g vs NW-g, P < 0.0001; PCOS-d vs OB-g, P < 0.0001).
|
30844044 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mapuche and European schoolchildren show higher levels of SBP with a decrease in sleep time of 30 min; however, there is a higher prevalence of hypertension and obesity in ethnic Mapuches than in European schoolchildren.
|
31361065 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, SHBG in women with PCOS and GDM and obesity was significantly lower than women with PCOS without GDM (MD = -38.14; 95% CI: [-56.79, -19.48]) and normal weight women (MD: -58.96; 95% CI: [-79.32, -38.59]).
|
31063851 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens.
|
29752333 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also in multivariate logistic regression model, for each increase of a child in the family the risk of abdominal obesity [OR: 0.95; 95% CI: 0.91-0.97), high SBP [OR: 0.88; 95% CI: 0.81-0.95)] and generalized obesity [OR: 0.95; 95% CI: 0.91-0.99)] decreased significantly.
|
29866072 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
HFD induced comparable obesity in control and <i>SHBG+</i> mice.
|
29141991 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated.
|
29770358 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interest in SHBG has escalated in recent years because of its inverse association with polycystic ovary syndrome (PCOS), obesity, insulin resistance, metabolic syndrome, and diabetes type II.
|
29227165 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI).
|
29474646 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
According to reduced sex hormone-binding globulin levels and increased free androgen index in the present study, obesity was linked with hyperandrogenism in female subjects.
|
30232779 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression.
|
29683196 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
SHBG is decreased in pregnant women with pregestational plus gestational obesity in association with common cardio-metabolic parameters.
|
30321217 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women.
|
29213285 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HtgW phenotype distinguishes itself from the (virtually neutral) simple abdominal obesity in independently conferring high CHD risk when elevated or reduced SHBG levels interact.
|
27846754 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Associations of SHBG with some anthropometric and metabolic variables in FDR suggests that lower levels is a marker for risk of developing T2D through obesity dependent metabolic pathways but low FAI is a better marker of state of diabetes in males.
|
28950181 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Metabolic component specific analysis showed that sex hormones were inversely associated with several components of MetS: TT with abdominal obesity, low high-density lipoprotein cholesterol (HDL-C) and high blood pressure; cFT with abdominal obesity and high blood pressure; SHBG with all components except high blood pressure.
|
28581026 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant additive interactions with obesity or central obesity were detected for total testosterone (RERI=2.75, 95% CI=0.92,4.59), SHBG (RERI=5.71, 95% CI=0.77,10.64), and FEI (RERI=-9.96, 95% CI=-19.18,-0.74) with regard to IR, beta-cell dysfunction, and T2D.
|
27914732 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant differences in SHBG were observed within the obesity status and gender, with discordant patterns of change in testosterone and estradiol.
|
28077498 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Familial presence of hypertension and/or obesity was significantly associated with SBP among adolescent females but not males.
|
28633388 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is of importance because reduction of SHBG plasma levels in obese and type 2 diabetic subjects could be directly associated with NAFLD development through an increase in hepatic lipogenesis.
|
28359088 |
2017 |