SHBG, sex hormone binding globulin, 6462

N. diseases: 368; N. variants: 20
Disease: Gestational Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 AlteredExpression phenotype BEFREE This systematic review showed that the level of SHBG is significantly lower in GDM pregnant women than that in healthy women. 31063851 2019
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 AlteredExpression phenotype BEFREE Transfection of SHBG into insulin-resistant cells may partially improve the level of GLUTs, providing a potential therapeutic approach for the treatment of insulin resistance in GDM. 31270755 2019
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 Biomarker phenotype BEFREE Multivariate analysis showed that FPG, non-high-density lipoprotein-cholesterol and SHBG are independent predictive factors for GDM. 29514404 2018
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 Biomarker phenotype BEFREE Decreased SHBG concentrations during the first trimester may predict GDM development. 29460646 2018
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 AlteredExpression phenotype BEFREE According to the results, low SHBG expression not only participates in the development of local insulin resistance, but may also play an important role in PI3K/AKT pathway-mediated systemic insulin resistance and gestational diabetes. 29298529 2018
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 GeneticVariation phenotype BEFREE Effect of placental sex hormone-binding globulin single nucleotide polymorphism rs6259 on protein and function in gestational diabetes mellitus. 29484425 2018
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 GeneticVariation phenotype BEFREE Logistic regression analysis showed that the preconception insulin under the curve (IAUC) and sex hormone-binding globulin (SHBG) levels were two most significant risk factors for developing GDM (p = 0.014; p = 0.042, respectively). 28277120 2017
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 Biomarker phenotype BEFREE Circulating concentrations of SHBG represent a potentially useful new biomarker for prediction of risk of GDM beyond the currently established clinical and demographic risk factors. 28279160 2017
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 Biomarker phenotype BEFREE Means HbA1c and SHBG were compared between glucose-intolerant versus normoglycemic women, and GDM versus no GDM women. 27613817 2017
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 AlteredExpression phenotype BEFREE Decreasing expression of SHBG may participate in regulation of insulin signaling, leading to a concomitant decrease in expression of relevant insulin signaling components in placental tissue, implying insulin resistance and eventual development of GDM. 27497146 2016
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 AlteredExpression phenotype BEFREE GDM serum and placental SHBG levels are reduced, hyperinsulinemia may lead to a reduction of SHBG in circulating blood, but also damage the placenta cells which led to placental synthesis and secretion of SHBG decrease. 23164471 2013
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 Biomarker phenotype BEFREE Compared to the controls, placental tissues from the GDM group displayed significantly decreased immunostaining rates for SHBG, as well as significantly lower levels of SHBG mRNA and protein expression (P<0.05). 22098307 2011
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 AlteredExpression phenotype LHGDN Sex hormone binding globulin offers a potential early marker to target women who are at risk for gestational diabetes mellitus. 12861158 2003