SHBG, sex hormone binding globulin, 6462

N. diseases: 150; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.500 Biomarker disease CTD_human Alcoholic hypogonadism: hormonal response to clomiphene. 8590623 1996
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.500 Biomarker disease PSYGENET This method of detection was used to determine the distribution of SHBG phenotypes in healthy controls of both sexes and in five different pathological conditions characterized by changes in the SHBG level or endocrine disturbances (malignant and benign ovarian neoplasms, hirsutism, liver cirrhosis and alcoholism). 8088001 1994
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates. 26050255 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Low plasma sex hormone-binding globulin (SHBG) levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk. 26441241 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 GeneticVariation disease BEFREE SHBG gene polymorphism (rs1799941) associates with metabolic syndrome in children and adolescents. 25647406 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 Biomarker disease BEFREE Low plasma sex hormone-binding globulin (SHBG) levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk. 26441241 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE These findings provide a potential mechanism to explain why low SHBG predicts the development of type 2 diabetes. 25226295 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 GeneticVariation disease BEFREE The plasma level of sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes, is subject to genetic, hormonal, metabolic, and nutritional regulation, and is a marker for the development of the metabolic syndrome and diabetes. 25226295 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 GeneticVariation disease BEFREE The relationship of sex hormone-binding globulin (SHBG) gene polymorphisms with serum SHBG level and metabolic syndrome in Chinese Han males. 24671943 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 GeneticVariation disease BEFREE Sex hormone binding globulin gene polymorphisms and metabolic syndrome in postmenopausal Turkish women. 23788303 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Single-nucleotide polymorphisms in the SHBG gene influence circulating SHBG levels in American patients with PCOS and may predict the development of type 2 diabetes. 23001781 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease CTD_human Polymorphisms in the SHBG gene are associated with risk of type 2 diabetes, but few studies have addressed SHBG as a predictor of CV events. 21982312 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE The correlation between SHBG and insulin resistance that is evident in a number of cross-sectional studies is in keeping with the suggestion that the association between SHBG and incidence of type 2 DM is explained by insulin resistance. 23121642 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE Measurements of SHBG are widely used to predict plasma free testosterone levels in patients suffering from excess androgen exposures, but have broader utility in assessing the risk for endocrine diseases and clinical sequelae of the metabolic syndrome, namely, type 2 diabetes and cardiovascular disease. 22531107 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Sex hormone-binding globulin and type 2 diabetes mellitus. 22047952 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 AlteredExpression disease BEFREE Measurements of SHBG are widely used to predict plasma free testosterone levels in patients suffering from excess androgen exposures, but have broader utility in assessing the risk for endocrine diseases and clinical sequelae of the metabolic syndrome, namely, type 2 diabetes and cardiovascular disease. 22531107 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Sex hormone-binding globulin genetic variation: associations with type 2 diabetes mellitus and polycystic ovary syndrome. 21178921 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Although SHBG SNPs associated with type 2 diabetes mellitus do not appear to be associated with PCOS status, rs1799941 and rs727428 genotypes are associated with SHBG levels independent of the effects of insulin resistance and obesity. 21252242 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 AlteredExpression disease BEFREE AChE activity was associated with BP status and SBP, whereas BChE activity was associated with features of the metabolic syndrome (especially body weight and BMI). 21493754 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 GeneticVariation disease BEFREE The (TAAAA)n polymorphism of the SHBG gene in men with the metabolic syndrome. 20690069 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE This mechanism provides a biological explanation for why SHBG is a sensitive biomarker of insulin resistance and the metabolic syndrome, and why low plasma SHBG levels are a risk factor for developing hyperglycemia and type 2 diabetes, especially in women. 19786070 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Possible mechanisms by which high circulating SHBG prevents the development of type 2 diabetes involve regulation of fasting glycemia but not alteration of insulin secretory function. 20841609 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE However, the AA genotype of SNP rs1800624 (-374T/A) was consistently associated with lower SBP [-5.0 mmHg (95% confidence interval -10.4 to 0.3)] and DBP [-4.2 (-7.2 to -1.3)], pulse pressure [-0.8 (-5.0 to 3.4)] as well as with less arterial stiffness [-0.56 SD (-1.04 to -0.09)] in individuals with normal glucose metabolism, but with higher SBP [6.2 (0.9-11.5)], DBP [2.1 (-0.7 to 5.0)] and pulse pressure [4.1 (-0.2 to 8.4)] in individuals with impaired glucose metabolism or type 2 diabetes mellitus (P for interaction <or=0.05 in all analyses). 20051912 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. 19933169 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.400 AlteredExpression disease BEFREE Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome. 19786070 2010