Anus, Imperforate
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
We studied a Korean family with six affected members with imperforate anus across three generations by whole exome sequencing and identified a missense mutation in the EBF2 gene (c.215C > T; p.Ala72Val).
|
29704291 |
2018 |
Anus, Imperforate
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
We studied a Korean family with six affected members with imperforate anus across three generations by whole exome sequencing and identified a missense mutation in the EBF2 gene (c.215C > T; p.Ala72Val).
|
29704291 |
2018 |
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
|
31420334 |
2019 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
Dupuytren Contracture
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.
|
28886342 |
2017 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
|
28739976 |
2017 |
Hernia, Inguinal
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.
|
26686553 |
2015 |
Malignant neoplasm of prostate
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
|
23535732 |
2013 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
|
23535732 |
2013 |
Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our research indicated that downexpression of miR-182-3p in OS cells results in overexpression of EBF2 and promotes the progression of OS.
|
30993113 |
2019 |
Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Additionally, EBF2 overexpression rescued the phenotype caused by miR-204-5p.Our data indicated that miR-204-5p is an anti-oncogenic miRNA in osteosarcoma which functions through inhibiting oncogenic transcription factor EBF2.
|
30529043 |
2019 |
Osteosarcoma of bone
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our research indicated that downexpression of miR-182-3p in OS cells results in overexpression of EBF2 and promotes the progression of OS.
|
30993113 |
2019 |
Osteosarcoma of bone
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Additionally, EBF2 overexpression rescued the phenotype caused by miR-204-5p.Our data indicated that miR-204-5p is an anti-oncogenic miRNA in osteosarcoma which functions through inhibiting oncogenic transcription factor EBF2.
|
30529043 |
2019 |
Childhood Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Additionally, EBF2 overexpression rescued the phenotype caused by miR-204-5p.Our data indicated that miR-204-5p is an anti-oncogenic miRNA in osteosarcoma which functions through inhibiting oncogenic transcription factor EBF2.
|
30529043 |
2019 |
Childhood Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our research indicated that downexpression of miR-182-3p in OS cells results in overexpression of EBF2 and promotes the progression of OS.
|
30993113 |
2019 |
Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
EBF2 up-regulation may be one of the mechanisms involved in the high levels of OPG in osteosarcoma, contributing to decrease TRAIL-induced apoptosis and leading to TRAIL resistance.
|
19671856 |
2009 |
Osteosarcoma of bone
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
EBF2 up-regulation may be one of the mechanisms involved in the high levels of OPG in osteosarcoma, contributing to decrease TRAIL-induced apoptosis and leading to TRAIL resistance.
|
19671856 |
2009 |
Childhood Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
EBF2 up-regulation may be one of the mechanisms involved in the high levels of OPG in osteosarcoma, contributing to decrease TRAIL-induced apoptosis and leading to TRAIL resistance.
|
19671856 |
2009 |
Diabetes
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overall, the study highlights the existence of novel regulatory mechanisms between Id1/PGC1α and Id1/Ebf2 in controlling brown fat metabolism, which has significant implications in the treatment of obesity and its associated diseases, such as diabetes.
|
28270523 |
2017 |
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
Overall, the study highlights the existence of novel regulatory mechanisms between Id1/PGC1α and Id1/Ebf2 in controlling brown fat metabolism, which has significant implications in the treatment of obesity and its associated diseases, such as diabetes.
|
28270523 |
2017 |