|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, our results demonstrated that aptamer ApC1 has high specificity to colorectal carcinoma Caco-2 cells, which could be further applied for targeted therapy of colorectal cancer in future studies.
|
30746785 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that an APC-regulated lncRNA-APC1 program is an exploitable therapeutic approach for the treatment of patients with CRC.
|
30511962 |
2019 |
|
Corneal Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
To date, 5 of the identified loci, at ANAPC1, ADAMTS8, ADAMTS17, ABCA6, and COL6A1, have not previously been reported as associated with corneal disease.
|
31246245 |
2019 |
|
Corneal Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Most notably, an intergenic variant close to ANAPC1 (rs78658973[A], frequency = 28.3%) strongly associates with decreased cell density and accounts for 24% of the population variance in cell density (β = -0.77 SD, P = 1.8 × 10<sup>-314</sup>) and associates with increased CH (β = 0.19 SD, P = 2.6 × 10<sup>-19</sup>) without affecting risk of corneal diseases and glaucoma.
|
30894546 |
2019 |
|
Glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Most notably, an intergenic variant close to ANAPC1 (rs78658973[A], frequency = 28.3%) strongly associates with decreased cell density and accounts for 24% of the population variance in cell density (β = -0.77 SD, P = 1.8 × 10<sup>-314</sup>) and associates with increased CH (β = 0.19 SD, P = 2.6 × 10<sup>-19</sup>) without affecting risk of corneal diseases and glaucoma.
|
30894546 |
2019 |
|
Keratoconus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The other loci were associated with keratoconus using TwinsUK (OR per effect allele for ADAMTS8, 0.51 [95% CI, 0.37-0.71; P = 7.9 × 10-5]; for COL6A1, 1.65 [95% CI, 1.05-2.59; P = .03]) or EPIC-Norfolk (OR per effect allele for ANAPC1, 0.78 [95% CI, 0.68-0.89; P = 3.7 × 10-4]; for ADAMTS17, 0.82 [95% CI, 0.68-0.99; P = .04]) controls.
|
31246245 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
None of the gastric cancer samples presented methylated DNA sequences for ANAPC1 and TP53.
|
18622497 |
2008 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
A decrease in lncRNA-APC1 expression was positively associated with lymph node and/or distant metastasis, a more advanced clinical stage, as well as a poor prognosis for patients with CRC.
|
30511962 |
2019 |
|
Nicotine Dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.
|
22377092 |
2012 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that an APC-regulated lncRNA-APC1 program is an exploitable therapeutic approach for the treatment of patients with CRC.
|
30511962 |
2019 |
|
Atrial Premature Complexes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that an APC-regulated lncRNA-APC1 program is an exploitable therapeutic approach for the treatment of patients with CRC.
|
30511962 |
2019 |
|
Carcinogenesis
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Thus, ANAPC1 and TP53 methylation was probably not implicated in gastric carcinogenesis in our samples.
|
18622497 |
2008 |
|
Stomach Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
None of the gastric cancer samples presented methylated DNA sequences for ANAPC1 and TP53.
|
18622497 |
2008 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the mutation of p31(comet), a recently identified mitotic checkpoint regulator, in human hepatocellular carcinoma.
|
17934339 |
2007 |
|
Prothrombin G20210A mutation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the influence of prothrombin G20210A mutation on the anticoagulant and fibrinolytic activities of APC (1 microg/ml).
|
16601829 |
2006 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results demonstrated that aptamer ApC1 has high specificity to colorectal carcinoma Caco-2 cells, which could be further applied for targeted therapy of colorectal cancer in future studies.
|
30746785 |
2019 |
|
Eczema
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Tonometry
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.
|
30054594 |
2018 |
|
Tonometry
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
|
29785010 |
2018 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |