|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the inhibitory effects of loquat leaf extract (LLE) on pancreatic α-amylase and α-glucosidase, and the preventative effects of LLE on hyperlipidemia and hyperglycemia in rats induced by a high fat and fructose diet have been evaluated.
|
28124052 |
2017 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of α-amylase and α-glucosidase enzymes using natural products (especially polyphenols) is a novel oral policy to regulate carbohydrate metabolism and hyperglycemia.
|
28470323 |
2017 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study also shows that n-hexane, chloroform, ethyl acetate and aqueous extracts of A. bracteosa root possess α-glucosidase inhibitory activities and therefore it may be used as hypoglycemic agents in the management of postprandial hyperglycemia.
|
28294059 |
2017 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our studies demonstrate that the dietary polyphenols resveratrol and piceatannol lower postprandial hyperglycemia and indicate that inhibition of intestinal α-glucosidase activity may be a potential mechanism contributing to their antidiabetic property.
|
28570943 |
2017 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results suggest that 2 has dual inhibitory activity against α-glucosidase and α-amylase and alleviates diabetic hyperglycemia and hyperlipidemia, making it a potential functional food ingredient and drug candidate for management of type 2 diabetes.
|
28132506 |
2017 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of α-amylase and α-glucosidase enzymes retards the rate of carbohydrate digestion, thereby provides an alternative and a less evasive strategy of reducing postprandial hyperglycaemia in diabetic patients.The AgNps derived from <i>O. sanctum</i> and <i>O. basilicum</i>, respectively displayed an inhibitory effect at 89.31 ± 5.32%, and 79.74 ± 9.51%, respectively, against <i>Bacillus stearothermophilus</i> α-glucosidase enzyme model, indicating an enhanced biocatalytic potential compared to their respective crude extracts and the control.
|
28855825 |
2017 |
|
Hyperglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the inhibitory effects of 2,7″-phloroglucinol-6,6'-bieckol on activities of α-glucosidase and α-amylase as well as its alleviating effect on postprandial hyperglycaemia in streptozotocin-induced diabetic mice.
|
28219252 |
2017 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that both products assayed could be effective in the management of postprandial hyperglycemia through inhibition of α-glucosidase in the small intestine.
|
28161878 |
2017 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
α-Glucosidase inhibitors (AGIs) have been reported for their clinical potential against postprandial hyperglycemia, which is responsible for the risks associated with diabetes mellitus 2 and cardiovascular diseases (CVDs).
|
28745232 |
2017 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that PB2 is useful for protection against hyperglycemia through inhibiting the activity of α-glucosidase.
|
30188554 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Efficacy of Alpha Glucosidase Inhibitor from Marine Actinobacterium in the Control of Postprandial Hyperglycaemia in Streptozotocin (STZ) Induced Diabetic Male Albino Wister Rats.
|
29755552 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The α-amylase and α-glucosidase inhibitory activities of UIOPS-1 were significantly increased after digestion indicating a good control of postprandial hyperglycemia (P<0.001).
|
29389616 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study provides new insight into the potential application of Lu'an GuaPian green tea as a functional food ingredient to regulate postprandial hyperglycemia through inhibition of α-glucosidase/α-amylase by FGs, particularly the mono- and di- glycosides of kaempferol.
|
29989631 |
2018 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
UIOPC also showed significant inhibitory capacity on α-amylase and α-glucosidase than UIOPS (P < 0.05), suggesting a good regulation of the postprandial hyperglycemia.
|
29689356 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The inhibition of α-glucosidase and α-amylase is a clinical strategy for the treatment of type II diabetes, and herbal medicines have been reported to credibly alleviate hyperglycemia.
|
30189596 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study has identified two novel and active α-glucosidase inhibitory peptides that could resist GIT digestion and therefore, have the potential to retard postprandial hyperglycemia in diabetic patients.
|
30096627 |
2018 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of α-glucosidase, a key carbohydrate hydrolyzing enzyme, could serve as one of the effective methodology in both preventing and treating diabetes through controlling the postprandial glucose levels and suppressing postprandial hyperglycemia.
|
29421697 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Scopoletin inhibits α-glucosidase in vitro and alleviates postprandial hyperglycemia in mice with diabetes.
|
30031794 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of α-glucosidase is an effective strategy for controlling the post-prandial hyperglycemia in diabetic patients.
|
30118991 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of α-glucosidase is an effective strategy for controlling post-prandial hyperglycemia in diabetic patients.
|
29223804 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
α-glucosidase is involved in the hydrolyses of disaccharide into monosaccharides and results in hyperglycemia.
|
29885400 |
2018 |
|
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study provides informative data on the potential α-glucosidase inhibitors identified in <i>C. nutans</i> leaves, indicating the plant's therapeutic effect to manage hyperglycemia.
|
30235889 |
2018 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of α-glucosidase activity is a prospective approach to prevent postprandial hyperglycemia.
|
31765755 |
2019 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
α-glucosidase inhibitors compete with the α-glucosidase enzyme activity, which helps to reduce the conversion of carbohydrates into glucose and thereby control the postprandial hyperglycemia incidence.
|
31808390 |
2019 |
|
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Functional foods that inhibit α-amylase and α-glucosidase activity are effective for regulating the blood glucose level and preventing hyperglycemia.
|
31613007 |
2019 |