Furthermore, an <i>in situ</i> examination of lung tissue showed that stromal fibroblasts expressed cancer-associated proteins from two procancer secretomes: one that included IL-6 (in cases of mild or no airflow obstruction), and one that included BMP1 (in cases of severe airflow obstruction).<b>Conclusions:</b> Two distinct stromal gene expression programs that promote cancer initiation are activated in patients with lung cancer depending on lung function.
Under acidic environment inside cancer cells, PCP NPs degraded, DOX was released from PCP-DOX-CM, and the fluorescence of DOX was activated, which was very specific for cancers with a high signal-to-noise ratio.
The transmembrane glycoprotein, CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein 1 (CDCP1) is overexpressed in several cancer types and is a predictor of poor prognosis for patients on standard of care therapies.
By analyzing a public database, we found that BMP receptor 2 (BMPR2) and BMP1 genes had mononucleotide repeats in their coding sequences that could be mutation targets in cancers with microsatellite instability (MSI).