|
Age related macular degeneration
|
0.190 |
Biomarker
|
disease |
BEFREE |
We identified four previously reported susceptibility loci showing genome-wide significant association with AMD progression: ARMS2-HTRA1 (P = 8.1 × 10-43), CFH (P = 3.5 × 10-37), C2-CFB-SKIV2L (P = 8.1 × 10-10) and C3 (P = 1.2 × 10-9).
|
29346644 |
2018 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of disease progression in age-related macular degeneration.
|
29346644 |
2018 |
|
Age related macular degeneration
|
0.190 |
Biomarker
|
disease |
BEFREE |
Further investigations are needed to validate the association and confirm the role of SKIV2L in AMD.
|
27484132 |
2017 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Haplotype and conditional analysis of the C2-CFB-SKIV2L locus showed a low-frequency variant (R74H) in CFB would be individually associated with AMD susceptibility independent of the GWAS associated SNP.
|
28173125 |
2016 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Among the SNPs, TNXB rs12153855 and FKBPL rs9391734 conferred an increased susceptibility to neovascular AMD (P = 2.8 × 10(-4) and 0.001, OR = 1.80 and 1.76, respectively), while SKIV2L exerted a protective effect on neovascular AMD (P = 2.2 × 10(-4), OR = 0.49).
|
26861912 |
2016 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Genotype distribution of rs1061170 (CFH), rs429608 (SKIV2L), rs2679798 (MYRIP) and both rs11549465 and rs11549467 (HIF1A) in AMD cases and healthy controls; association between genotypes and AMD subtypes.
|
24995509 |
2015 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
A SKIV2L variant was associated with protection against exudative AMD regardless of subtypes in the Japanese population.
|
24865191 |
2014 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
|
23577725 |
2013 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
The association of SKIV2L rs429608 with neovascular AMD remained significant after adjusting for CFH rs800292 and HTRA1 rs11200638.
|
23260260 |
2013 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
|
23577725 |
2013 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.
|
22694956 |
2012 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
|
21909106 |
2011 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.190 |
Biomarker
|
disease |
BEFREE |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
We performed an association analysis between PCV and polymorphisms across the C2-CFB-RDBP-SKIV2L region in a Japanese population, genotyping 13 single nucleotide polymorphisms (SNPs) spanning this region, including rs9332739 (E318D), rs547154, rs4151667 (L9H), and rs641153 (rs641153" genes_norm="629">R32Q) that are known to be associated with age-related macular degeneration (AMD).
|
19556007 |
2009 |