|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although CD150 was not found in different regions of normal brain tissues, our immunohistochemical study revealed its expression in 77.6% of human CNS tumors, including glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, ependymoma, and others.
|
25710480 |
2015 |
|
Adult Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Canine lymphoid cell lines and neoplastic B and T lymphocytes collected from dogs with spontaneous lymphoma expressed the Morbillivirus receptor CD150 mRNA.
|
15746063 |
2005 |
|
Asymptomatic human immunodeficiency virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the expression and function of SLAM on CD4(+) and CD8(+) lymphocytes in HIV-infected individuals with either recently acquired infection (Group A) or asymptomatic HIV infection (Group B) and in healthy controls (HC).
|
10479532 |
1999 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity.
|
18482989 |
2008 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
These new insights into the multiplicity of roles played by the SLAM/CD2 family and its potential importance in human autoimmunity positions the SLAM/CD2 family as an excellent target for immunotherapy.
|
21094032 |
2010 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Furthermore, evidence has been accumulating that SLAM family members are potential targets for inflammatory and autoimmune diseases.
|
29729453 |
2018 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be involved in the development of autoimmunity in mice.
|
24373350 |
2014 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Signaling lymphocytic activation molecule (SLAM) family receptors have been implicated in normal immunity, immunodeficiencies and autoimmunity.
|
23731618 |
2013 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome.
|
15589166 |
2004 |
|
Autoimmune thyroid disease (AITD)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression levels and the function of SLAMF1 in lymphocytes in AITD patients and controls.
|
27854550 |
2017 |
|
Autoimmune thyroiditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression and Function of the Costimulatory Receptor SLAMF1 Is Altered in Lymphocytes From Patients With Autoimmune Thyroiditis.
|
27854550 |
2017 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The SLAM receptor is located in lymphoid cells; therefore, the infection of these cells by CDV leads to immunosuppression, the severity of which can lead to variability in the clinical disease with the potential of secondary bacterial infection, up to and including the development of neurological signs in its later stage.
|
30845967 |
2019 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our findings demonstrated suggestive associations of AEI polymorphisms with breast cancer risk (MUC16 rs2591592 and SLAMF1 rs1061217) and prognosis (ZNF331 rs8109631 and CHRAC1 rs10216653).
|
27128794 |
2017 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A measles virus selectively blind to signaling lymphocytic activation molecule shows anti-tumor activity against lung cancer cells.
|
26317644 |
2015 |
|
Central Nervous System Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Although CD150 was not found in different regions of normal brain tissues, our immunohistochemical study revealed its expression in 77.6% of human CNS tumors, including glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, ependymoma, and others.
|
25710480 |
2015 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although CD150 was not found in different regions of normal brain tissues, our immunohistochemical study revealed its expression in 77.6% of human CNS tumors, including glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, ependymoma, and others.
|
25710480 |
2015 |
|
Childhood Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Canine lymphoid cell lines and neoplastic B and T lymphocytes collected from dogs with spontaneous lymphoma expressed the Morbillivirus receptor CD150 mRNA.
|
15746063 |
2005 |
|
Chronic Lymphocytic Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
TCL1, CCR7, FCRL2, FCRL3, and CD150) as additional potential markers with prognostic relevance in CLL.
|
20923685 |
2011 |
|
Chronic Lymphocytic Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia.
|
22194822 |
2011 |
|
Chronic Lymphocytic Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
CD150 or CD180 crosslinking on CLL B cells alone led to activation of Akt, mTORC1, ERK1/2, p38MAPK and JNK1/2 networks.
|
28982149 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Herein, we found a significant upregulation of signaling lymphocytic activation molecule family member 3 (SLAMF3) expression on T cells from T2D patients compared to those of healthy controls.
|
31332162 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the study demonstrates that variants of SLAMF1 and ITLN1, both implicated in inflammation, are associated with type 2 diabetes in Indians.
|
22277902 |
2012 |
|
Eczema
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Epstein-Barr Virus Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Deficiency of SAP (SLAM (signaling lymphocyte activation molecule)-associated protein) protein is associated with a severe immunodeficiency, the X-linked lymphoproliferative disease (XLP) characterized by an inappropriate immune reaction against Epstein-Barr virus infection often resulting in a fatal clinical course.
|
12766168 |
2003 |