|
Myopia
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Myopia
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Two recent large-scale genome-wide association studies identified significant associations between myopia and single nucleotide polymorphisms (SNPs) near the PRSS56, BMP3, KCNQ5, LAMA2, TOX, TJP2, RDH5, ZIC2, RASGRF1, GJD2, RBFOX1, and SHISA6 genes.
|
25587058 |
2015 |
|
Myopia
|
0.120 |
Biomarker
|
disease |
BEFREE |
Our comparison with two previous studies suggested that BMP3 SNPs cause myopia primarily in Caucasian populations, while they may exhibit protective effects in Asian populations.
|
25335978 |
2014 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
When test results for BMP3 and NDRG4 were combined, the DOR of CRC detection was 98.36, which was higher than that for BMP3 and NDRG4 separately.
|
31097151 |
2020 |
|
Colorectal Carcinoma
|
0.070 |
PosttranslationalModification
|
disease |
BEFREE |
In an analysis of stool samples from 3 independent studies of 332 patients with IBD, we associated levels of methylation at 2 genes (BMP3 and VAV3), relative to level of methylation at ZDHHC1, with detection of CRC and HGD.
|
29775793 |
2019 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Though BMP3 is a reliable biomarker for screening CRC, the molecular mechanism of BMP3 in carcinogenesis remains largely unknown.
|
31665064 |
2019 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In this paper, we describe the recent advances in non-invasive CRC screening and more specifically in molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions.
|
26401070 |
2015 |
|
Colorectal Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Ingenuity pathway analysis mapped three of these markers (GAS7, BMP3 and GPR) in the insulin and TGF-β1 network-the two key pathways in CRC.
|
24441198 |
2014 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate BMP3 disruption in CRCs in relation to both the traditional and serrated pathways of tumor progression.
|
18311777 |
2008 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Four genes specifically methylated in colorectal cancer [bone morphogenetic protein 3 (BMP3), EYA2, aristaless-like homeobox-4 (ALX4), and vimentin] were selected from 41 candidate genes and evaluated on 74 cancers, 62 adenomas, and 70 normal epithelia.
|
18086775 |
2007 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
BMP3 was further knocked down or overexpressed in CRC cells, and the effects on cell growth of xenograft tumors in nude mice were assessed.
|
31665064 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The biomarkers of a currently in-use multi-target stool DNA test (K-ras, NDRG4, and BMP3) and eight newly characterized methylated biomarkers were commonly expressed in tumor tissue specimens, independent of FIT result.
|
28044229 |
2017 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The methylation levels of the SFRP, TFPI2, NDRG4 and BMP3 promoters in tumor tissues were significantly higher than those in normal-appearing tissue (SFRP2, p=0.013; TFPI2, p<0.001; NDRG4, p=0.003; BMP3, p=0.001).
|
27114416 |
2016 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Fifty CpG sites located within CpG islands-in genes ATXN7L1 (2), BMP3 (7), EID3 (15), GAS7 (1), GPR75 (24), and TNFAIP2 (1)-were significantly hypermethylated in tumor vs. normal tissues (P<0.05).
|
24441198 |
2014 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Although disrupted BMP signalling in tumor development has more recently been investigated, a role for BMP3 in colorectal cancer (CRC) has remained largely unexplored.
|
18311777 |
2008 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
After the identification of hypermethylation of BMP3 CpG islands by bisulfite genomic sequencing (BGS), we further investigated the relationship of BMP3 expression and gastric carcinogenesis by Western blot analysis and gel electrophoresis mobility shift assay (EMSA).
|
30992671 |
2019 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Though BMP3 is a reliable biomarker for screening CRC, the molecular mechanism of BMP3 in carcinogenesis remains largely unknown.
|
31665064 |
2019 |
|
Carcinogenesis
|
0.030 |
PosttranslationalModification
|
phenotype |
BEFREE |
Interestingly, the BMP3 gene methylation rate was 71.05% and 28.58%, respectively, in MSI positive and negative cases (P = 0.031), suggesting that BMP3 genetic instability and promoter methylation are initiated during gastric carcinogenesis.
|
20238409 |
2010 |
|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In combination with the data from clinical research, bioinformatics analysis and experimental verification, we propose that 1, 25-hydroxylvitamin D<sub>3</sub> affects gastric cancer progression by repressing BMP3 promoter methylation.
|
30992671 |
2019 |
|
Stomach Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Promotor region methylation of the BMP3 gene may cause gastric carcinoma in Chinese people.
|
20238409 |
2010 |
|
Adenocarcinoma of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To compare the nature of these transcripts in different tissues, three cDNA clones encoding BMP-3 have been isolated by reverse transcription-polymerase chain reaction (RT-PCR) and cDNA library screening from human prostate cancer PC-3 cells, rat prostate adenocarcinoma PA III cells, and primary FRC cells.
|
7880444 |
1995 |
|
Adenocarcinoma of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Normal rat ventral prostate expressed all these BMP mRNAs, but the rat prostate adenocarcinoma PAIII expressed predominantly BMP 3 mRNA.
|
8146069 |
1994 |
|
Low Back Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
BMP-3 Promotes Matrix Production in Co-cultured Stem Cells and Disc Cells from Low Back Pain Patients.
|
31578928 |
2020 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analyses of BMP3 function in colon cancer cell proliferation, migration, invasion, and apoptosis were performed using HCT116 and KM12 cells.
|
31665064 |
2019 |