|
Acute leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia.
|
7808005 |
1994 |
|
Acute leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia.
|
16614510 |
2006 |
|
Acute lymphocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We found a concomitant increase in mdr1 and mrp gene expression combined with a decreased expression of topoisomerase II alpha in the course of the second relapse of an acute lymphoblastic leukemia (ALL).
|
7914748 |
1994 |
|
Acute lymphocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Analysis of paired samples, the first obtained at diagnosis and the second at relapse, from 13 acute myelogenous leukemia (AML) and four acute lymphocytic leukemia (ALL) patients showed that MRP expression was increased at the time of relapse in greater than 80% of patients.
|
7528566 |
1995 |
|
Acute lymphocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
P-glycoprotein (P-gp), lung resistance-related protein (LRP) and multidrug resistance-associated protein (MRP) expression, and blast cell intracellular daunorubicin accumulation (IDA) were evaluated in 95 previously untreated cases of adult acute lymphoblastic leukaemia (ALL) using flow cytometry.
|
11849207 |
2002 |
|
Acute lymphocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
In contrast, low MRP expression levels were detected in acute lymphocytic leukemia (n = 14), and in chronic myelocytic leukemia (n = 9).
|
7911548 |
1994 |
|
Acute lymphocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
MRP gene expression was found to be higher in patients with relapsed de novo AML compared to those at presentation but prior therapy did not affect MRP gene expression in ALL.
|
7808005 |
1994 |
|
Acute lymphocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Bone marrow aspirates from 30 children with a diagnosis of acute lymphoblastic leukemia were assessed for the expression of messenger RNA for the MDR-1, MRP and LRP genes by semi-quantitative RT-PCR.
|
15543372 |
2004 |
|
Acute monocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In contrast, samples of AML obtained at the time of relapse contained approximately twofold higher levels of MRP RNA (P < .01).
|
7528566 |
1995 |
|
Acute monocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, high MRP expression was more frequent in the FAB M5 subtype as compared to the other subtypes.
|
9815827 |
1997 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of MRP expression in newly diagnosed AML samples were similar to those observed in normal bone marrow cells (CD34-negative and CD34-positive) and in unselected HL60 human promyelocytic leukemia cells, which were used as an internal control throughout this study.
|
7528566 |
1995 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The NSCLC showing high (++) levels of MRP gene expression (19 out of 33, 57.6%) were predominantly squamous cell carcinomas (Ad, 5; Sq, 13; La, 1) (P < 0.05).
|
7669560 |
1995 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The study was undertaken to clarify the relationship of the 190k protein to MRP gene expression in non-P-glycoprotein-containing MDR cells of the large-cell and adenocarcinoma lung cancer lines, COR-L23 and MOR.
|
7903701 |
1994 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MRP expression in 4 squamous-cell carcinomas (L13, 18, 19 and 20) was more than 3.6 times higher than in KB-3-1 cells, and the average MRP mRNA expression level of all squamous-cell carcinomas was significantly higher than that of adenocarcinoma of the lung and of colorectal and gastric carcinomas.
|
8603824 |
1996 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
According to the results of IHA, the 33 parathyroid adenomas were separated into four groups: (1) 2 adenomas with both positive Pgp and positive MRP expression, (2) 1 adenomas with positive Pgp but negative MRP expression, (3) 2 adenomas with negative Pgp but positive MRP expression, and (4) 28 adenomas with both negative Pgp and negative MRP expression.
|
11929704 |
2002 |
|
Adenomatous Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
38 of 54 (70%) CRCs, 16 of 35 (46%) CIAs and 3 of 40 (8%) adenomatous polyps were MRP positive (chi 2 test, P < 0.0001).
|
10533474 |
1999 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found a concomitant increase in mdr1 and mrp gene expression combined with a decreased expression of topoisomerase II alpha in the course of the second relapse of an acute lymphoblastic leukemia (ALL).
|
7914748 |
1994 |
|
Adult Acute Myeloblastic Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Clinical resistance to chemotherapy in acute myeloid leukemia (AML) is associated with the expression of the multidrug resistance (MDR) proteins P-glycoprotein, encoded by the MDR1/ABCB1 gene, multidrug resistant-related protein (MRP/ABCC1), the lung resistance-related protein (LRP), or major vault protein (MVP), and the breast cancer resistance protein (BCRP/ABCG2).
|
17340137 |
2007 |
|
Adult Acute Myeloblastic Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In two multidrug resistant (MDR) sublines of the HL-60 human acute myeloid leukemia (AML) cell line which overexpress MRP but not P-glycoprotein, the assay detects elevated levels of MRP mRNA (4- to 8-fold) relative to the drug-sensitive parental cells (designated HL-60/W).
|
8558937 |
1996 |
|
Adult Acute Myeloblastic Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients.
|
9616142 |
1998 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The properties of glioblastoma and astrocytoma stem-like cells on anti-apoptotic and MRP genes are: anti-apoptotic gene livin and survivin are elevated in CSCs but are the most increased in just differentiated CSCs; MRP1 gene is significantly increased and MRP3 is decreased in CSCs, but when differentiating the MRP3 gene starts a remarkable increase in CSCs; the expression of anti-apoptotic and MRP genes shows no differences between the CSCs isolated from glioblastoma and astrocytoma tissues.
|
18462887 |
2008 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
No appreciable correlation was found between liver cancer 99mTc-MIBI images and expression of MRP or LRP on the level of protein or mRNA.
|
15112342 |
2004 |
|
Adult Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MRP levels were also evaluated in 16 newly diagnosed, untreated lymphoma patient samples.
|
9160686 |
1997 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of the MDR1 and MRP genes in patients with lymphoma with primary bone marrow involvement.
|
15560070 |
2004 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This suggests the possible role of multidrug resistance (MDR), albeit atypical (which means it does not involve the usual MDR1 and MRP glycoproteins), in medulloblastoma's CP-resistance.
|
18473730 |
2008 |