MARCKSL1, MARCKS like 1, 65108

N. diseases: 169; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.010 Biomarker disease BEFREE All these results indicated that MLP-1 can effectively inhibit renal fibrosis and potentially treat DN. 30521918 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.010 Biomarker disease BEFREE The lipolytic protein LipU was conserved in mycobacterium sp. including M. tuberculosis (MTB LipU) and M. leprae (MLP LipU). 29557724 2019
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma
0.010 Biomarker disease BEFREE PLAC8 blockade using siRNA reversed chemotherapy resistance and downregulated MRP and MDR1 in SGC966GR and SGC966OR cells, suggesting that PLAC8 mediates chemotherapy resistance in GBC. 31272718 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.010 Biomarker disease BEFREE The purpose of this study was to introduce a multiphase MRA collateral imaging method (collateral map) derived from time-resolved dynamic contrast-enhanced MRA and to verify the value of the multiphase MRA collateral map in acute ischemic stroke by comparing it with the multiphase collateral imaging method (MRP collateral map) derived from dynamic susceptibility contrast-enhanced MR perfusion. 31097431 2019
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.010 Biomarker disease BEFREE Based on these criteria, there were 18 epitopes that stimulated specific immune responses: squamous cell carcinoma antigen recognized by T cells (SART)1<sub>690</sub> , P53<sub>161</sub> , multidrug resistance-associated protein (MRP)3<sub>503</sub> , Survivin2B<sub>80</sub> , melanoma-associated antigen (MAGE)-A4<sub>143</sub> , receptor tyrosine kinase ErbB-2/neu (Her2/neu)<sub>63</sub> , Wilms tumour (WT1)<sub>235</sub> , WT1<sub>417</sub> , β-catenin<sub>29</sub> , carcinoembryonic antigen (CEA)<sub>268</sub> , CEA<sub>652</sub> , epithelial cell adhesion molecule (EpCAM)<sub>173</sub> , enhancer of zeste homolog (EZH)2<sub>291</sub> , mucin 5AC (MUC5AC)<sub>716</sub> , glypican-3 (GPC3)<sub>298</sub> and kinesin family member 20A (KIF20A)<sub>66</sub> . 29790264 2018
CUI: C3840565
Disease: Autoimmune thyroid disease (AITD)
Autoimmune thyroid disease (AITD)
0.010 AlteredExpression disease BEFREE In addition, mRNA expression of MRP proteins in PBMCs and the thyroid gland was markedly elevated in AITD patients. 29656212 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 Biomarker disease BEFREE We found BMDN-treated with f-MLP or that were exposed to sepsis by CLP had increased Rac1 signaling, whereas the cells pretreated with MSP68 had significantly reduced Rac1 activation (P < 0.05). 27993196 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.010 GeneticVariation group BEFREE Using a database of 420 CT images of the skull, each extractor was applied with the classifiers such as MLP, SVM, kNN, OPF and Bayesian to classify if a CT image represented a healthy brain or one with an ischemic or hemorrhagic stroke. 28774437 2017
CUI: C0206139
Disease: Lichen Planus, Oral
Lichen Planus, Oral
0.010 Biomarker disease BEFREE The genes such as TNF, CARD11, MRP genes and CCND1 may be potential therapeutic target genes in OLP. 28237528 2017
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 Biomarker disease BEFREE We found BMDN-treated with f-MLP or that were exposed to sepsis by CLP had increased Rac1 signaling, whereas the cells pretreated with MSP68 had significantly reduced Rac1 activation (P < 0.05). 27993196 2017
Malignant neoplasm of urinary bladder
0.010 AlteredExpression disease BEFREE In conclusion, a significant upregulation of MRP and downregulation of Topo II were detected in the ADM‑resistant human bladder cancer cell line (pumc‑91/ADM) compared with in the parental cell line (pumc‑91). 27748815 2016
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.010 AlteredExpression disease BEFREE In conclusion, a significant upregulation of MRP and downregulation of Topo II were detected in the ADM‑resistant human bladder cancer cell line (pumc‑91/ADM) compared with in the parental cell line (pumc‑91). 27748815 2016
CUI: C0007115
Disease: Malignant neoplasm of thyroid
Malignant neoplasm of thyroid
0.010 AlteredExpression disease BEFREE GSEA clearly showed that the expression of OxPhos and MRP gene sets was significantly lower in primary thyroid cancer than in matched normal thyroid tissue. 25590838 2015
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.010 AlteredExpression disease BEFREE GSEA clearly showed that the expression of OxPhos and MRP gene sets was significantly lower in primary thyroid cancer than in matched normal thyroid tissue. 25590838 2015
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.010 AlteredExpression disease BEFREE GSEA clearly showed that the expression of OxPhos and MRP gene sets was significantly lower in primary thyroid cancer than in matched normal thyroid tissue. 25590838 2015
CUI: C0015967
Disease: Fever
Fever
0.010 AlteredExpression phenotype BEFREE Treatment with mitomycin C decreased MRP expression at high concentrations and hyperthermia intensified these effects. 23378758 2013
CUI: C0265294
Disease: Pyle metaphyseal dysplasia
Pyle metaphyseal dysplasia
0.010 GeneticVariation disease BEFREE Cartilage-hair-hypoplasia is a rare autosomal recessive metaphyseal dysplasia due to RMRP (the RNA component of the RNase MRP ribonuclease mitochondrial RNA processing complex) gene mutations. 23643676 2013
CUI: C3160889
Disease: Node-negative breast cancer
Node-negative breast cancer
0.010 Biomarker disease BEFREE In conclusion, MARCKSL1 has strong prognostic value in lymph node-negative breast cancer patients, especially in those with high proliferation. 22772381 2012
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.010 GeneticVariation group BEFREE Circulation 101:2674-2677, 2000) and MLP mutations are able to cause hypertrophic and dilated forms of cardiomyopathy in humans (Bos et al. 21484537 2011
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera
0.010 Biomarker disease BEFREE Ex vivo experiments revealed that basophils from patients with polycythemia vera were hypersensitive to the priming effect of interleukin-3 and to f-MLP-induced activation; pre-treatment with a JAK2 inhibitor reduced polycythemia vera basophil activation. 19608683 2009
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma
0.010 Biomarker disease BEFREE Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma: further exploring the role of P53 and WT1 gene. 18972317 2009
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.010 Biomarker disease BEFREE MRP3 was the predominant MRP isoform in gallbladder carcinomas (93%) and cholangiocellular carcinomas (57%), whereas MRP2 expression was detected in only 29% of gallbladder carcinomas and was undetectable in cholangiocellular carcinomas. 18226047 2008
CUI: C0278510
Disease: Childhood Medulloblastoma
Childhood Medulloblastoma
0.010 Biomarker disease BEFREE This suggests the possible role of multidrug resistance (MDR), albeit atypical (which means it does not involve the usual MDR1 and MRP glycoproteins), in medulloblastoma's CP-resistance. 18473730 2008
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma
0.010 Biomarker disease BEFREE This suggests the possible role of multidrug resistance (MDR), albeit atypical (which means it does not involve the usual MDR1 and MRP glycoproteins), in medulloblastoma's CP-resistance. 18473730 2008
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.010 Biomarker disease BEFREE The properties of glioblastoma and astrocytoma stem-like cells on anti-apoptotic and MRP genes are: anti-apoptotic gene livin and survivin are elevated in CSCs but are the most increased in just differentiated CSCs; MRP1 gene is significantly increased and MRP3 is decreased in CSCs, but when differentiating the MRP3 gene starts a remarkable increase in CSCs; the expression of anti-apoptotic and MRP genes shows no differences between the CSCs isolated from glioblastoma and astrocytoma tissues. 18462887 2008