MARCKSL1, MARCKS like 1, 65108

N. diseases: 169; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung
0.050 Biomarker disease BEFREE The human small cell lung cancer NCI-H69 cell line selected for resistance to etoposide (H69/VP) has been reported previously to sequentially overexpress both the MRP and MDR1 multidrug resistance-conferring genes. 9377550 1997
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung
0.050 Biomarker disease BEFREE The present results indicate that MRP probably confers intrinsic multidrug resistance in NSCLC rather than in SCLC. 9413193 1998
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung
0.050 Biomarker disease BEFREE Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4. 8980384 1996
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung
0.050 AlteredExpression disease BEFREE Using an RNase protection assay we have analyzed the expression of MRP in non-Pgp MDR sublines of the human lung cancer cell lines SW-1573 (non-small cell lung cancer) and GLC4 (small cell lung cancer). 8467491 1993
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung
0.050 Biomarker disease BEFREE Factors for which there is now substantial clinical evidence of a link to small cell lung cancer (SCLC) resistance to chemotherapy include MRP (for platinum-based combination chemotherapy) and MDR1/P-gp (for non-platinum agents). 20047843 2010