MARCKSL1, MARCKS like 1, 65108

N. diseases: 169; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.070 Biomarker disease BEFREE Amplification and expression of the ABC transporters ARA and MRP in a series of multidrug-resistant leukaemia cell sublines. 9649117 1998
CUI: C0023418
Disease: leukemia
leukemia
0.070 AlteredExpression disease BEFREE DNA analysis by Southern blotting did not reveal amplification of the MRP gene in the leukemia samples, including those with elevated MRP mRNA levels. 7911548 1994
CUI: C0023418
Disease: leukemia
leukemia
0.070 AlteredExpression disease BEFREE Pgp activity was higher in CD34+ leukemia than in CD34- leukemia (2.26 +/- 1.50 v 1.46 +/- 1.21, respectively; P = .003), and MRP activity was higher in CD34- leukemia than in CD34+ leukemia (1.77 +/- 0.40 v 1.4 +/- 0.29, respectively; P = .004). 9616142 1998
CUI: C0023418
Disease: leukemia
leukemia
0.070 AlteredExpression disease BEFREE Sequential emergence of MRP- and MDR1-gene over-expression as well as MDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines. 8575859 1996
CUI: C0023418
Disease: leukemia
leukemia
0.070 AlteredExpression disease BEFREE Southern blot analysis did not reveal amplification of the MRP gene in the leukaemia samples with elevated MRP mRNA levels. 7803281 1994
CUI: C0023418
Disease: leukemia
leukemia
0.070 GeneticVariation disease BEFREE These findings provide important insight into the biology of inversion 16 leukaemia and suggest that MRP deletion, as detected by molecular analysis, may have a key role in determining outcome in patients with inversion 16 AML. 7911871 1994
CUI: C0023418
Disease: leukemia
leukemia
0.070 Biomarker disease BEFREE We conclude that hyperexpression of MRP is observed in leukaemias, and that further studies are needed to assess the clinical relevance of MRP. 8833393 1996