MARCKSL1, MARCKS like 1, 65108

N. diseases: 169; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.070 AlteredExpression disease BEFREE To address this hypothesis, we have examined the relationship between MYCN and MRP gene expression in neuroblastoma tumours and cell lines. 9516823 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.070 AlteredExpression disease BEFREE The forced expression of N-myc failed to enhance the expression of MRP in N-myc transfected neuroblastoma cell lines. cMOAT was rarely expressed in the neuroblastomas, but was frequently expressed in the malignant liver tumors. 10081488 1998
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.070 AlteredExpression disease BEFREE To clarify the role of MDR1 in this malignancy, we examined the relationship between MDR1 expression and patient outcome in subsets of 60 primary untreated neuroblastomas for which MYCN gene copy number and expression of the multidrug resistance-associated-protein (MRP) gene had been previously characterised. 9516848 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.070 AlteredExpression disease BEFREE The effect of MYCN down-regulation on MRP expression and response to cytotoxic drugs was investigated in NBL-S neuroblastoma cells transfected with MYCN antisense RNA constructs. 10348353 1999
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.070 AlteredExpression disease BEFREE Our results give evidence that MDR in neuroblastomas might be caused by multiple resistance factors and that a higher proliferation rate of neuroblastoma cells possibly based on altered MYCN gene expression is associated with enhanced MRP, CYCA and TOPO IIalpha gene expression. 10425316 1999
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.070 AlteredExpression disease BEFREE Expression of the MRP gene is thus common in both primary neuroblastoma tumors and cultured cell lines, and correlates with amplification and overexpression of the N-myc oncogene, which is central to the malignant phenotype of this disease. 7923112 1994
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.070 AlteredExpression disease BEFREE High levels of MRP gene expression in patients with neuroblastoma correlate strongly with poor outcome. 8532000 1996