MARCKSL1, MARCKS like 1, 65108

N. diseases: 169; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.070 AlteredExpression disease BEFREE Using an RNase protection assay we have analyzed the expression of MRP in non-Pgp MDR sublines of the human lung cancer cell lines SW-1573 (non-small cell lung cancer) and GLC4 (small cell lung cancer). 8467491 1993
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.070 AlteredExpression disease BEFREE In conclusion, we have shown that a human revertant lung cancer cell line (COR-L23/Rev) has the ability to recover quickly, similar levels of MRP expression and resistance as COR-L23/R after a transient exposure to the MDR-drugs doxorubicin and vincristine. 9014757 1996
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.070 Biomarker disease BEFREE Our results suggest that MRP may be implicated in drug resistance in unselected lung-cancer cell lines and its role in normal lung and primary lung cancer warrants further investigation in patients undergoing chemotherapy. 8647646 1996
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.070 Biomarker disease BEFREE The multidrug resistance-associated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several drug-selected lung cancer cell lines. 9334814 1997
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.070 Biomarker disease BEFREE The multidrug resistance-associated protein (MRP) gene is thought to play an important role in MDR in lung cancer. 9272120 1997
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.070 AlteredExpression disease BEFREE Multidrug resistance-associated protein (MRP) mRNA expression and drug sensitivity in lung cancer cells were examined, and the effects of verapamil, a modulating agent for MRP, on drug sensitivity were also tested. 9413193 1998
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.070 GeneticVariation disease BEFREE To this end, we took advantage of the fact that the overexpression of MDR1 and MRP genes, two genes known to be associated with the development of drug resistance, is very common in lung cancer. 9713512 1998