MARCKSL1, MARCKS like 1, 65108

N. diseases: 169; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 Biomarker disease BEFREE MLP immunoreactivity was decreased approximately 50% (P<0.05) in the left ventricular myocardium of patients with chronic heart failure due to dilated or ischemic cardiomyopathy compared with non-failing donor hearts. 10851202 2000
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 Biomarker disease BEFREE In vivo analysis revealed that MLP-deficient mice reproduce the morphological and clinical picture of dilated cardiomyopathy and heart failure in humans, providing the first model for this condition in a genetically manipulatable organism. 9039266 1997
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 Biomarker disease BEFREE In summary, MLP-deficient hESC-CMs recapitulate the pathogenesis of HCM and its progression toward HF, providing an important human model for investigation of CSRP3/MLP-associated disease pathogenesis. 31406109 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 Biomarker disease BEFREE Conversely, gene-deleted mice lacking both Mg29 and MLP protein showed a further reduction in t-tubule organization and accelerated heart failure. 28706255 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 AlteredExpression disease BEFREE Our results suggest that the main role of MLP in heart lies in the direct inhibition of PKCα and that chronic uninhibited PKCα activity at the intercalated disc in the absence of functional MLP leads to heart failure. 27353086 2016
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 GeneticVariation disease BEFREE We have further investigated the muscle LIM protein knockout model of HF (MLP-/-), which closely parallels human dilated cardiomyopathy disease progression and aberrant beta-adrenergic signaling, and their betaARKct rescue. 17971502 2008
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 Biomarker disease BEFREE To investigate whether alterations in betaAR function contribute to the development of myocardial failure, transgenic mice with cardiac-restricted overexpression of either a peptide inhibitor of betaARK1 or the beta2AR were mated into a genetic model of murine heart failure (MLP-/-). 9618528 1998
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.080 Biomarker disease BEFREE Interestingly, MLP was also found to be down-regulated in humans with heart failure (Zolk et al. 21484537 2011