MARCKSL1, MARCKS like 1, 65108

N. diseases: 169; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 Biomarker disease BEFREE The multidrug resistance-associated protein (MRP) gene is thought to play an important role in MDR in lung cancer. 9272120 1997
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 Biomarker disease BEFREE The multidrug resistance-associated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several drug-selected lung cancer cell lines. 9334814 1997
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 GeneticVariation disease BEFREE To this end, we took advantage of the fact that the overexpression of MDR1 and MRP genes, two genes known to be associated with the development of drug resistance, is very common in lung cancer. 9713512 1998
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 AlteredExpression disease BEFREE In conclusion, we have shown that a human revertant lung cancer cell line (COR-L23/Rev) has the ability to recover quickly, similar levels of MRP expression and resistance as COR-L23/R after a transient exposure to the MDR-drugs doxorubicin and vincristine. 9014757 1996
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 Biomarker disease BEFREE Expression of gamma-glutamylcysteine synthetase (gamma-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates with exposure of human lung cancers to platinum drugs. 9569044 1998
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 AlteredExpression disease BEFREE In most lung cancers, this resistance is associated with the overexpression of (a) multidrug resistance-associated protein (MRP) responsible for drug efflux from the cancer cells (pump resistance) and (b) BCL2 protein that activates antiapoptotic cellular defense (nonpump resistance). 15342407 2004
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 AlteredExpression disease BEFREE Using an RNase protection assay we have analyzed the expression of MRP in non-Pgp MDR sublines of the human lung cancer cell lines SW-1573 (non-small cell lung cancer) and GLC4 (small cell lung cancer). 8467491 1993
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 AlteredExpression disease BEFREE All cell lines except one and all normal lung tissues and primary non-small-cell lung cancers expressed detectable levels of MRP. 8647646 1996
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.090 AlteredExpression disease BEFREE Multidrug resistance-associated protein (MRP) mRNA expression and drug sensitivity in lung cancer cells were examined, and the effects of verapamil, a modulating agent for MRP, on drug sensitivity were also tested. 9413193 1998