|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
|
17035674 |
2007 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chronic nitrate supplementation in obese type 2 diabetic rats improved glucose tolerance, insulin resistance, and dyslipidemia; these favorable effects were associated with increased mRNA and protein expression of GLUT4 and decreased mRNA expression of iNOS in insulin-sensitive tissues, and with decreased gluconeogenesis, inflammation, and oxidative stress.
|
29432804 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GLUT4 expression is up-regulated by exercise training and thyroid hormone treatment and is down-regulated by fasting, streptozotocin-induced diabetes, obesity, high-fat diet, and denervation.
|
9405224 |
1997 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of GLUT4 mRNA were similarly not affected by obesity, IGT, or NIDDM whether normalized per RNA or for the amount of an unrelated constitutive mRNA species.
|
1535055 |
1992 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objectives of this study were to (1) determine the expression of the insulin-sensitive GLUT4 glucose transporter and IR in the syncytiotrophoblast plasma membranes across gestation in normal pregnancy and in pregnancies complicated by maternal obesity and (2) assess the effect of insulin on GLUT4 plasma membrane trafficking in human placental explants.
|
31112275 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, it seems that at this stage caveolins and GLUT-4 are regulated independently of the insulin pathway, through a mechanism that could be mediated by inflammation and oxidative stress associated with obesity.
|
20506294 |
2010 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Type 2 diabetes mellitus and obesity are associated with impaired regulation of GLUT4 gene expression and elevated levels of free fatty acids and proinflammatory factors.
|
17317207 |
2007 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of the gene encoding RBP4 was increased in the adipose tissue, but not in the liver, of insulin-resistant adipose GLUT4(-/-) mice and five other mouse models of obesity and insulin resistance.
|
18598108 |
2008 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose consumption.
|
30742994 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
H(2) significantly increased skeletal muscle membrane Glut4 expression and markedly improved glycemic control in STZ-induced type 1 diabetic mice after chronic intraperitoneal (i.p.) and oral (p.o.) administration.However, long-term p.o. administration of H(2) had least effect on the obese and non-insulin-dependent type 2 diabetes mouse models.
|
23326534 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data demonstrate that GLUT4 is present in the endometrium of normal and PCOS subjects and that hyperinsulinism and obesity seem to have a negative effect on endometrial GLUT4 expression in PCOS.
|
15292352 |
2004 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the case of the coexistence of depression and obesity, the most important changes were (1) the decrease in the membrane form of GLUT4, which may suggest weaker insulin action in the frontal cortex, and (2) the diminished GLP-1R, which could cause neurodegenerative changes in the hippocampus.
|
31782099 |
2020 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
AnkB variants that fail to restore normal lipid accumulation and GLUT4 localization in adipocytes are present in 1.3% of European Americans and 8.4% of African Americans, and are candidates to contribute to obesity susceptibility in humans.
|
29133412 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
GLUT4 function is impaired in obesity and type 2 diabetes leading to hyperglycemia and an increased risk of cardiovascular disease and neuropathy.
|
25596527 |
2015 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.
|
2354749 |
1990 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the late 1980s, when GLUT4, the major insulin-regulated glucose transporter, was identified, my lab observed that it was downregulated in adipocytes but not in skeletal muscle in insulin-resistant states, such as obesity and type 2 diabetes, in humans and rodents.
|
30573674 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that baicalin is a powerful and promising agent for treatment of obesity and insulin resistance via Akt/AS160/GLUT4 and P38MAPK/PGC1α/GLUT4 pathway.
|
28359800 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The similar results in lean PCOS and control subjects suggest that endometrial GLUT4 expression is not affected by PCOS itself, whereas it is reduced by obesity in PCOS patients.
|
15731326 |
2004 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings showed that adipose GLUT4 gene expression changes were more related to insulin resistance and type 2 diabetes rather than to obesity.
|
21604201 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
To gain insight into the molecular pathogenesis of obesity and specifically the role of nutrient partitioning in the development of obesity, we overexpressed the insulin-responsive glucose transporter (GLUT4) in transgenic mice under the control of the fat-specific aP2 fatty acid-binding protein promoter/enhancer.
|
8226728 |
1993 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
GLUT4 defects in adipose tissue are early signs of metabolic alterations in Alms1GT/GT, a mouse model for obesity and insulin resistance.
|
25299671 |
2014 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that GSE prevented the obesity and related metabolic disorders in HF-fed mice by regulating insulin sensitivity and GLUT4 expression as well as by preventing the oxidative stress and inflammation in skeletal muscle and adipose tissue.
|
28840618 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In normal, obese and T2D cells: A) BRS-3-AP as insulin enhanced BRS-3 and GLUT-4 mRNA/protein levels; improving glucotransporter translocation to plasma membrane, and B) BRS-3-AP caused a concentration-related-stimulation of glucose transport, being obese and T2D myocytes more sensitive to the ligand than normal.
|
23291341 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, the effects of LLAE on body weight, fat mass, glucose and lipid metabolism and the expression of PPARγ2, insulin receptor substrate 1 and glucose transporter 4 (GLUT4) in visceral adipose tissue (VAT) were measured in HFD-induced obese rats treated with low or high dose [0.5 or 3.0 g crude drug/(kg.d)] LLAE for 6 weeks.
|
28690544 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mice overexpressing the Glut4 glucose transporter in adipocytes have elevated lipogenesis and increased glucose tolerance despite being obese with elevated circulating fatty acids.
|
25303528 |
2014 |