SLC2A4, solute carrier family 2 member 4, 6517

N. diseases: 158; N. variants: 7
Disease: Impaired glucose tolerance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE The present findings showed that administration of baicalein decreased pP38MAPK, pERK and PPARγ levels, but enhanced pAKT, PGC-1α and UCP1 contents as well as GLUT4 expression in adipocytes, and reversed high fat diet-induced glucose intolerance, hyperglycemia and insulin resistance in diet-induced obese mice. 30308480 2018
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. 27797912 2017
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE T<sub>4</sub> attenuated glucose intolerance by 15% and decreased IR index (IRI) by 34% in T<sub>4</sub>-treated OLETF compared to untreated OLETF despite a 31% decrease in muscle Glut4 mRNA expression. 27980001 2017
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE These results strongly suggest that fermented tea activates both PI3K/Akt- and AMPK-dependent signaling pathways to induce GLUT4 translocation and increases the expression of insulin receptor to improve glucose intolerance. 23106150 2012
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Our findings implicate the muscular GLUT4 system in the glucose intolerance of liver cirrhosis by a mechanism different from that in diabetes. 17448565 2007
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype LHGDN Our findings implicate the muscular GLUT4 system in the glucose intolerance of liver cirrhosis by a mechanism different from that in diabetes. 17448565 2007
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE In NSY mice, atorvastatin accelerated glucose intolerance as a result of insulin resistance and decreased SLC2A4 expression in WAT. 16685502 2006
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE They develop fasting hyperglycemia and glucose intolerance and are at risk for greater insulin resistance than mice lacking GLUT4 in only one tissue. 15578099 2004
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Skeletal muscle GLUT 4 expression is normal in obesity, impaired glucose tolerance (IGT), GDM, and NIDDM, indicating that functional activity or translocation of GLUT 4 may be impaired.4. 8087095 1994
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE However, in vastus lateralis, relative amounts of GLUT4 per milligram membrane protein were similar (NS) among lean (1.0 +/- 0.2) and obese (1.5 +/- 0.3) subjects and patients with IGT (1.4 +/- 0.2) and NIDDM (1.2 +/- 0.2). 1535055 1992
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Suppression of GLUT 4 mRNA is observed in patients with impaired glucose tolerance, and therefore, may occur early in the evolution of diabetes. 1999488 1991