BMP4, bone morphogenetic protein 4, 652

N. diseases: 423; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033375
Disease: Prolactinoma
Prolactinoma
0.540 Biomarker disease BEFREE Moreover, the role of BMP-4 which stimulates prolactinoma development through the Smad signalling cascade is described and its role as putative drug target for the treatment of prolactinomas is discussed. 31705792 2020
CUI: C0033375
Disease: Prolactinoma
Prolactinoma
0.540 AlteredExpression disease BEFREE BMP-4 transcript and protein are differentially expressed and show increase in the majority of prolactinomas relative to normal pituitary, whereas the majority of other adenoma subtypes show reduced expression relative to both prolactinoma and normal pituitaries. 22700770 2012
CUI: C0033375
Disease: Prolactinoma
Prolactinoma
0.540 AlteredExpression disease BEFREE PDGFA was significantly upregulated in treated prolactinomas, while BMP4 was significantly downregulated in treated prolactinomas. 22366961 2012
CUI: C0033375
Disease: Prolactinoma
Prolactinoma
0.540 AlteredExpression disease BEFREE The differential expression and action of BMP-4 in prolactinomas and corticotrophinomas highlights the importance of studying a gene with contrasting actions in two cell lineages of the same organ in order to understand the pituitary transformation process. 19407504 2009
CUI: C0033375
Disease: Prolactinoma
Prolactinoma
0.540 Biomarker disease CTD_human Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-Beta(TGF-Beta) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. 16809920 2006
CUI: C0033375
Disease: Prolactinoma
Prolactinoma
0.540 Biomarker disease RGD BMP-4 stimulates, and noggin blocks, cell proliferation and the expression of c-Myc in human prolactinomas, whereas BMP-4 has no action in other human pituitary tumors. 12552124 2003