Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
: The increasing utilization of SGLT2 inhibitor in patients with type 2 diabetes mellitus will inevitably lead to more cases of eDKA seen in the ED.
|
31027990 |
2019 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Euglycemic Diabetic Ketoacidosis with Elevated Acetone in a Patient Taking a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor.
|
27717592 |
2017 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Euglycemic diabetic ketoacidosis (eDKA) is however challenging to identify in the emergency department (ED) due to absence of marked hyperglycemia, often leading to delayed diagnosis and treatment. eDKA has been recently found to be associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors, one of the newest classes of antidiabetics, though there are very limited reports implicating dapagliflozin as the offending agent in ED patients.
|
29923997 |
2018 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Euglycemic diabetic ketoacidosis (DKA) is a known complication of sodium-glucose co-transporter 2 (SGLT-2) inhibitors that have been reported in the literature.
|
31489272 |
2019 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sodium glucose cotransporter 2 inhibitors have increased risk of urogenital infections and possible risk of "euglycaemic" diabetic ketoacidosis.
|
29320602 |
2018 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SGLT2 inhibitor-induced euglycaemic diabetic ketoacidosis may be due to abrupt, severe and transient impaired glucose sensing in susceptible individuals with a hitherto unrecognised beta cell SGLT variant.
|
29602453 |
2018 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sodium glucose cotransporter 2 inhibitors are currently widely used antihyperglycaemic medications that are considered to be associated with euglycaemic diabetic ketoacidosis.
|
30968118 |
2019 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Areas covered: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been linked with the scarce, but serious, complication of euglycemic diabetic ketoacidosis, as well as with an increase in serum potassium, magnesium and phosphorus levels.
|
28748724 |
2017 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both drug classes are associated with the rare but serious life-threatening complications that result from metabolic acidosis, including lactic acidosis (with metformin) and euglycemic diabetic ketoacidosis (with SGLT2 inhibitors).
|
30639796 |
2019 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In rare cases, SGLT2 inhibitors administration may be followed by euglycemic diabetic ketoacidosis.
|
27819144 |
2017 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SGLT-2 inhibitor-associated EDKA also indicates a necessary review of our previous understanding of "diabetic" ketoacidosis, since the SGLT-2 inhibitor predisposes patients to DKA in a "starvation" way.
|
30369948 |
2018 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This report highlights the importance of recognizing EDKA as a complication of oral anti-diabetics and discontinuing SGLT-2 inhibitors days prior to surgery and ICU admission.
|
31259114 |
2019 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed a literature review of this topic and discuss the pathophysiology, diagnosis, management, and prevention of SGLT2-inhibitor-induced euDKA.
|
31218148 |
2019 |
Euglycaemic diabetic ketoacidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report the case of a 51-year-old woman admitted to the acute medical unit with abdominal pain and vomiting, who was diagnosed with euglycaemic diabetic ketoacidosis secondary to recent initiation of an SGLT2-i medication (dapagliflozin).
|
31537607 |
2019 |