Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
NIS has been exploited for over 75 years in ablative radioiodine (RAI) treatment of thyroid cancer, where its ability to transport radioisotopes depends on its localization to the plasma membrane.
|
31672844 |
2020 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Enhancement of <sup>211</sup>At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer.
|
30796173 |
2019 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sodium/iodide symporter (NIS)-mediated iodide uptake plays an important physiological role in regulating thyroid gland function, as well as in diagnosing and treating Graves' disease and thyroid cancer.
|
31331356 |
2019 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Sodium Iodide Symporter (NIS), responsible for active transport of iodide into thyroid cells, allows the use of radioactive iodine (RAI) as the systemic treatment of choice for TC metastatic disease.
|
31590142 |
2019 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These preliminary data suggest that assessment of the NIS expression and EMT phenotypes of CTCs may serve as potential adjuncts for predicting and monitoring the curative effect of RAI therapy in DTC patients and avoid ineffective treatment.Further validation is warranted.
|
31147861 |
2019 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic Modifications in Thyroid Cancer Cells Restore NIS and Radio-Iodine Uptake and Promote Cell Death.
|
29561759 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Noninvasive imaging of iodide uptake via the sodium/iodide symporter (NIS) has received great interest for evaluation of thyroid cancer and reporter imaging of NIS-expressing viral therapies.
|
29198608 |
2018 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Non-invasive NIS imaging with radioactive iodides and iodide analogs has gained much interest in recent years for evaluation of thyroid cancer and NIS reporter expression.
|
30083270 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Radioactive iodide has been the mainstay adjuvant treatment for thyroid cancer for the last seven decades by virtue of its active transport by NIS.
|
29437784 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thyroid iodide uptake, mediated by the sodium-iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy.
|
29160164 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, our results elucidate a pump-independent, protumorigenic role for NIS in thyroid cancer via its cross-talk with PTEN signaling.<b>Significance:</b> A novel pump-independent protumorigenic role of nonmembranous NIS challenges the presumption that radioiodine treatment of thyroid cancer is ineffective when transmembrane NIS is not expressed.<i></i>.
|
30217930 |
2018 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of the sodium-iodide symporter (NIS) and the resistance to post-operative radioactive iodide treatment is a crucial cause of higher mortality of some thyroid cancer patients.
|
29495389 |
2018 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, analysis of publicly available datasets of thyroid carcinomas revealed that high LAT1 expression is associated with potentially untreatable PTC presenting reduced NIS/SLC5A5 transcription and with ATC.
|
30241549 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These studies evaluating the etiological roles of these factors in linking breast and thyroid cancer might also improve our understanding and identify new therapeutic approaches, such as sodium/iodide symporter-mediated radioiodine therapy and thyroid-stimulating hormone receptor antagonists, for breast cancer.
|
29976206 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Selumetinib Activity in Thyroid Cancer Cells: Modulation of Sodium Iodide Symporter and Associated miRNAs.
|
30018229 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Radioiodine whole body scan (WBS), related to sodium iodide symporter (NIS) function, is widely used to detect recurrence/metastasis in postoperative patients with thyroid cancer.
|
28386277 |
2017 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study explored the combined cytotoxic effects of adenovirus-mediated CD and NIS under the control of the progression elevated gene-3 (<i>PEG-3</i>) promoter (Ad-PEG-3-CD-NIS) with Na<sup>131</sup>I/5-FC against the human thyroid cancer TT cell line <i>in vitro</i>.
|
29344184 |
2017 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thyroid concentrates radioactive iodine by sodium-iodide symporter; this is used for treating hyperthyroidism and thyroid cancer.
|
28283939 |
2017 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cell penetrating peptide of sodium-iodide symporter effect on the I-131 radiotherapy on thyroid cancer.
|
28450931 |
2017 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data support further translational studies with <sup>18</sup>F-TFB as NIS gene reporter and imaging biomarker for thyroid cancer and other disease processes that import iodide.
|
29080017 |
2017 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abundant sodium/iodide symporter protein expression in thyroid cancer cells under these conditions was confirmed by immunofluorescent microscopy.
|
26751190 |
2016 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MicroRNAs let7 expression in thyroid cancer: correlation with their deputed targets HMGA2 and SLC5A5.
|
26960757 |
2016 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The sodium/iodide symporter (NIS) is involved in iodide uptake and has been used for the diagnosis and treatment of thyroid cancer.
|
26115738 |
2015 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study has uncovered the existence of a miR-146b-3p/PAX8/NIS regulatory circuit that may be exploited therapeutically to modulate thyroid cell differentiation and iodide uptake for improved treatment of advanced thyroid cancer.
|
26282166 |
2015 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
NIS is clinically very relevant because it allows the treatment with radioiodine of thyroid cancer patients.
|
24708099 |
2014 |