Orthostatic intolerance
|
0.610 |
GeneticVariation
|
phenotype |
LHGDN |
It has been proposed that a mutation in exon 9 of the norepinephrine transporter gene (Ala457Pro), resulting in more than 98% loss of function compared with the wild type, might provide a pathogenetic mechanism to explain the clinical symptoms of patients with OI.
|
12589229 |
2003 |
Orthostatic intolerance
|
0.610 |
Biomarker
|
phenotype |
CTD_human |
Here the hypothesis that abnormal norepinephrine transporter (NET) function might contribute to the pathophysiology in some patients with OI was tested.
|
11458707 |
2001 |
Orthostatic intolerance
|
0.610 |
GeneticVariation
|
phenotype |
UNIPROT |
In a patient with orthostatic intolerance and her relatives, we measured postural blood pressure, heart rate, plasma catecholamines, and systemic norepinephrine spillover and clearance, and we sequenced the norepinephrine-transporter gene and evaluated its function.
|
10684912 |
2000 |
Orthostatic intolerance
|
0.610 |
GermlineCausalMutation
|
phenotype |
ORPHANET |
In a patient with orthostatic intolerance and her relatives, we measured postural blood pressure, heart rate, plasma catecholamines, and systemic norepinephrine spillover and clearance, and we sequenced the norepinephrine-transporter gene and evaluated its function.
|
10684912 |
2000 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Then, we analyzed the expression of NET correlation with inflammatory cytokines to provide a new direction for detecting the association mechanism between depression and hypertension.
|
30957546 |
2020 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans.
|
31442583 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression.
|
30773040 |
2019 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, we found two genes, SLC6A4 and SLC6A2, to be the main therapeutic targets, and Serotonin-Norepinephrine Reuptake Inhibitors (SNRI) and Tricyclic Antidepressants (TCA) to be the most effective drugs for individuals with depression at risk for suicide.
|
29331709 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The norepinephrine transporter occupancy at week 2 in hypothalamus but not in other regions predicted improvement in depression as reflected by reduction in MADRS scores from baseline to week 7.
|
29016993 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The locus coeruleus (LC), which has high NET concentration, has been attributed to brain networks involved in depression.
|
30238915 |
2018 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension.
|
28737436 |
2017 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults.
|
28068779 |
2017 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
|
25990886 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients.
|
25650523 |
2015 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients.
|
25650523 |
2015 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide.
|
24655776 |
2014 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children.
|
25422957 |
2014 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide.
|
24655776 |
2014 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Compared with VM rats, the PM rats showed significant relief of depression-like behaviors, decrease in the malondialdehyde level, increase in superoxide dismutase and catalase activities, and increase in 5-HTT and NET expression.
|
23636256 |
2013 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.
|
23969988 |
2013 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.
|
23969988 |
2013 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The present findings demonstrate that corticosterone up-regulates the expression and function of NET in vitro, indicating the action of corticosterone on the noradrenergic phenotype may play an important role in the correlation between stress and the development of depression.
|
20070865 |
2010 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It was shown that the NET-T182C, interacting with 5-HTTLPR, was associated with the susceptibility to depression.
|
19468717 |
2009 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD.
|
18973248 |
2009 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
RGD |
Here we sought to determine if alpha-Syn, or the other synuclein family members, beta-synuclein (beta-Syn) and gamma-synuclein (gamma-Syn), modulate NET activity in an animal model of depression, the Wistar-Kyoto (WKY) rat.
|
18800064 |
2009 |