SLC6A2, solute carrier family 6 member 2, 6530

N. diseases: 238; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1535893
Disease: Orthostatic intolerance
Orthostatic intolerance
0.610 GeneticVariation phenotype LHGDN It has been proposed that a mutation in exon 9 of the norepinephrine transporter gene (Ala457Pro), resulting in more than 98% loss of function compared with the wild type, might provide a pathogenetic mechanism to explain the clinical symptoms of patients with OI. 12589229 2003
CUI: C1535893
Disease: Orthostatic intolerance
Orthostatic intolerance
0.610 Biomarker phenotype CTD_human Here the hypothesis that abnormal norepinephrine transporter (NET) function might contribute to the pathophysiology in some patients with OI was tested. 11458707 2001
CUI: C1535893
Disease: Orthostatic intolerance
Orthostatic intolerance
0.610 GeneticVariation phenotype UNIPROT In a patient with orthostatic intolerance and her relatives, we measured postural blood pressure, heart rate, plasma catecholamines, and systemic norepinephrine spillover and clearance, and we sequenced the norepinephrine-transporter gene and evaluated its function. 10684912 2000
CUI: C1535893
Disease: Orthostatic intolerance
Orthostatic intolerance
0.610 GermlineCausalMutation phenotype ORPHANET In a patient with orthostatic intolerance and her relatives, we measured postural blood pressure, heart rate, plasma catecholamines, and systemic norepinephrine spillover and clearance, and we sequenced the norepinephrine-transporter gene and evaluated its function. 10684912 2000
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE Then, we analyzed the expression of NET correlation with inflammatory cytokines to provide a new direction for detecting the association mechanism between depression and hypertension. 30957546 2020
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans. 31442583 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. 30773040 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE In addition, we found two genes, SLC6A4 and SLC6A2, to be the main therapeutic targets, and Serotonin-Norepinephrine Reuptake Inhibitors (SNRI) and Tricyclic Antidepressants (TCA) to be the most effective drugs for individuals with depression at risk for suicide. 29331709 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The norepinephrine transporter occupancy at week 2 in hypothalamus but not in other regions predicted improvement in depression as reflected by reduction in MADRS scores from baseline to week 7. 29016993 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The locus coeruleus (LC), which has high NET concentration, has been attributed to brain networks involved in depression. 30238915 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension. 28737436 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. 28068779 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression. 25990886 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients. 25650523 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients. 25650523 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide. 24655776 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide. 24655776 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Compared with VM rats, the PM rats showed significant relief of depression-like behaviors, decrease in the malondialdehyde level, increase in superoxide dismutase and catalase activities, and increase in 5-HTT and NET expression. 23636256 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population. 23969988 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population. 23969988 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE The present findings demonstrate that corticosterone up-regulates the expression and function of NET in vitro, indicating the action of corticosterone on the noradrenergic phenotype may play an important role in the correlation between stress and the development of depression. 20070865 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE It was shown that the NET-T182C, interacting with 5-HTTLPR, was associated with the susceptibility to depression. 19468717 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. 18973248 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease RGD Here we sought to determine if alpha-Syn, or the other synuclein family members, beta-synuclein (beta-Syn) and gamma-synuclein (gamma-Syn), modulate NET activity in an animal model of depression, the Wistar-Kyoto (WKY) rat. 18800064 2009