Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia.
|
28416295 |
2017 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people.
|
28454051 |
2017 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed after antipsychotic treatment and (ii) whether treatment with different generations of antipsychotics influenced the DAT availability after follow-up for 6 months.
|
28027110 |
2017 |
Cocaine Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between the Intron 8 VNTR Polymorphism of the DAT1 Gene and Crack Cocaine Addiction.
|
29332099 |
2017 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that rare high-risk CNVs affecting the gene encoding the dopamine transporter contribute to the pathogenesis of schizophrenia and affective disorders.
|
26559242 |
2016 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increased Nigral SLC6A3 Activity in Schizophrenia Patients: Findings From the Toronto-McLean Cohorts.
|
26707863 |
2016 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined whether single nucleotide polymorphisms (SNPs) in SLC6A3, SLC6A4 were associated with schizophrenia in Han Chinese people (893 schizophrenia patients and 611 healthy controls).
|
25019689 |
2014 |
PARKINSONISM-DYSTONIA, INFANTILE, 1
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood.
|
24613933 |
2014 |
PARKINSONISM-DYSTONIA, INFANTILE, 1
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood.
|
24613933 |
2014 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Identification of the mRNA expression status of the dopamine D2 receptor and dopamine transporter in peripheral blood lymphocytes of schizophrenia patients.
|
24086483 |
2013 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes.
|
22438288 |
2013 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
An attractive model to study processes related to neurodevelopment in schizophrenia is reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and differentiating them into different neuronal lineages. iPSCs from three schizophrenia patients and from two controls were reprogrammed from hair follicle keratinocytes, because of their accessibility and common ectodermal origin with neurons. iPSCs were differentiated into Pax6(+)/Nestin(+) neural precursors and then further differentiated into β3-Tubulin(+)/tyrosine hydroxylase(+)/DAT(+) dopaminergic neurons.
|
23732879 |
2013 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the DAT1 gene (rs2975223 and rs2455391) were tested in 368 patients with schizophrenia and 420 healthy controls, of whom 293 patients underwent an assessment of psychotic symptoms through the positive and negative syndrome scale (PANSS).
|
22366190 |
2012 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This first hand evidence, regarding BDNF and DAT1 gene methylation and their expression profile with risk of schizophrenia, indicated a significant function for the BDNF gene in the development of schizophrenia.
|
23065263 |
2012 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
DAT KO mice mirror certain symptoms evident in patients with schizophrenia, such as the psychomotor agitation, stereotypy, deficits of prepulse inhibition and cognitive impairments.
|
23240026 |
2012 |
PARKINSONISM-DYSTONIA, INFANTILE, 1
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
Genetic mapping and exome sequencing identify variants associated with five novel diseases.
|
22279524 |
2012 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function.
|
21150910 |
2011 |
PARKINSONISM-DYSTONIA, INFANTILE, 1
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study.
|
21112253 |
2011 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of the DAT1 gene may play a role in increasing susceptibility to schizophrenia, but does not affect the severity of psychotic symptoms in Han Chinese.
|
19879111 |
2010 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between several functional polymorphisms in genes coding for dopamine metabolism and transport enzymes (MAO-A VNTR; MAO-A 941T>G; DAT VNTR; DAT -67A/T; CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*6) and the frequency of schizophrenia.
|
20041956 |
2010 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We previously detected association between SZ and intronic SLC6A3 variants that replicated in two independent Caucasian samples, but had no obvious function.
|
20957647 |
2010 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence that a genetic variant in the DRD2 gene and possible interaction between DRD3 and SLC6A3 genes are associated with schizophrenia.
|
19766158 |
2010 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
To fully evaluate SLC6A3 as a therapeutic antipshycotic target we investigated association of the gene with responses to chlorpromazine and clozapine and with chlorpromazine-induced extrapyramidal syndrome (EPS) in the Chinese schizophrenia population.
|
20580759 |
2010 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus the aim of the present study was to investigate the possible association between a new single nucleotide polymorphism (rs6347) located in exon 9 of the protein transporter (SLC6A3) and schizophrenia.
|
21049181 |
2010 |
Cocaine Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD.
|
20170711 |
2010 |