Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated Beta-amyloid peptide for Alzheimer's disease (AD), Alpha-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson's disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington's gene mutations in Huntington's disease (HD).
|
15538967 |
2004 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Thus, allelic variants in SLC6A3, which affect gene expression, are associated with PD in this population and may interact with occupational pesticide exposure to increase PD risk.
|
16963468 |
2006 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Twenty-six patients are reported.Three patients had dementia with Lewy bodies; one had an atypical parkinsonism; 22 had PD, including one with schizophrenia and neuroleptic exacerbated, dopamine transporter scan-positive idiopathic PD; and another had PD complicated by strokes.
|
30004964 |
2018 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
One had PD and another had mild parkinsonian signs plus reduced dopamine transporter uptake in the striatum.
|
30195197 |
2018 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The analyses examined: (i) 1-year changes in free water in 103 de novo patients with Parkinson's disease and 49 controls; (ii) 2- and 4-year changes in free water in a subset of 46 patients with Parkinson's disease imaged at baseline, 12, 24, and 48 months; (iii) whether 1- and 2-year changes in free water predict 4-year changes in the Hoehn and Yahr scale; and (iv) the relationship between 4-year changes in free water and striatal binding ratio in a subgroup of Parkinson's disease who had undergone both diffusion and dopamine transporter imaging.
|
28899020 |
2017 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
DAT imaging and clinical biomarkers in relatives at genetic risk for LRRK2 R1441G Parkinson's disease.
|
26686514 |
2016 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD.
|
18973248 |
2009 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the presence of PD-related human α-synuclein A53T mutant or dopamine transporter (DAT) blockers also differentially affects the dopamine output in striosomes and matrix.
|
28706191 |
2017 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
DAT imaging may be useful in STN-DBS candidate selection and the identification of the therapeutic mechanism of STN-DBS in patients with advanced PD and motor symptom fluctuations.
|
29406893 |
2018 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine whether a multiparametric scoring system (MSS) could improve accuracy compared to each parameter of DAT-SPECT and NmMRI in differentiating PD from NDPS.
|
29804474 |
2019 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The susceptibility of some people to PD may be conferred by polymorphisms in the dopamine-transporter gene that could lead to increased cellular accumulation of neurotoxic compounds in dopaminergic neurons.
|
9380062 |
1997 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the association of striatal dopamine transporter (DAT) loss with cognitive function and cerebral cortical metabolism in PD.
|
31584466 |
2019 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study investigated whether the degree of reduced striatal dopamine transporter binding at diagnosis of PD predicts later motor complications and time to disease progression.
|
29801899 |
2018 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In patients with PD, serum IGF-1 levels were negatively correlated with age and modified Rankin scale (mRS) scores and positively correlated with the striatal dopamine transporter-specific binding ratio and the frontal assessment battery score.
|
30903695 |
2019 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Participants belonging to the following cohorts of the Parkinson Progression Markers Initiative (PPMI) study were included: de novo PD with dopamine transporter binding deficit (n = 423), idiopathic REM sleep behavior disorder (RBD, n = 39), hyposmia (n = 26) and non-PD mutation carrier (NMC; Leucine-rich repeat kinase 2 (LRRK2) G2019S (n = 88) and glucocerebrosidase (GBA) gene (n = 38) mutations)).
|
30125297 |
2018 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate a possible relationship between DRD2/ANKK1 (rs1800497) and SLC6A3/DAT1 (rs28363170) gene polymorphisms with the response to levodopa (L-DOPA)-therapy in patients with Parkinson's disease (PD).
|
30353564 |
2019 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Imaging technologies such as dopamine transporter imaging currently offer the highest degree of accuracy for identifying premotor PD, but they are expensive as screening tools, and abnormalities on these studies would only be evident at Braak Stage 3 or higher.
|
22508279 |
2012 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease.
|
29112012 |
2018 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dopamine transporter imaging and positron emission tomography showed that the degree of nigral neuronal loss and nigrostriatal depletion were severe and appeared greater even than that seen in idiopathic Parkinson's disease.
|
23625061 |
2013 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study analyzed data from dopamine transporter (DAT) positron emission tomographic scans of 282 male patients with de novo Parkinson disease to investigate whether smoking impacts striatal dopamine neuronal degeneration.
|
29059491 |
2017 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study is to identify the dopamine transporter activity of the corpus striatum and thalamus according to myocardial <sup>123</sup>I-MIBG uptake in PD.
|
30796009 |
2019 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied 51 subjects with Parkinson's disease (PD) (18 non-demented, 24 demented, and 9 dementia with Lewy bodies) and 127 with atypical parkinsonian syndromes (47 multiple system atrophy (MSA), 38 progressive supranuclear palsy (PSP), and 42 corticobasal syndrome (CBS)) with <sup>18</sup>F-fluorodeoxyglucose PET to quantify the expression of previously validated disease-related patterns for PD, MSA, PSP, and CBS and <sup>18</sup>F-fluoropropyl-β-CIT PET to quantify caudate and putamen dopamine transporter (DAT) binding.
|
26980757 |
2017 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Impairments in gait kinematics and postural control may not correlate with dopamine transporter depletion in individuals with mild to moderate Parkinson's disease.
|
30589477 |
2019 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Whereas all examined striatal (caudate and putamen) dopamine neuronal markers are decreased in Parkinson's disease, levels of only some (dopamine, dopamine transporter) but not others (dopamine metabolites, synthetic enzymes, vesicular monoamine transporter 2) are below normal in methamphetamine users.
|
27519465 |
2017 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Two hundred and seven patients with de novo drug-naïve PD underwent dopamine transporter (DAT) positron emission tomography and brain MRI scanning.
|
28951497 |
2018 |