|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to report long-lasting effects of bupropion on brain dopamine transporter (DAT) in a patient with depression and parkinsonism.
|
31361666 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
|
31537790 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overall, these results suggest that low DAT levels, in the Nacc, might act as protective factors against anxiety and depression.
|
30367968 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
At baseline, 51.6% of 397 patients had normal caudate dopamine transporter binding, 26.0% had unilateral caudate involvement, 22.4% had bilaterally impaired caudate.Compared with those with a baseline normal caudate function, at the4-year follow-up patients with a baseline bilateral caudate involvement showed a higher frequency of cognitive impairment (p<0.001) and depression (p<0.001), and worse cognitive (p<0.001), depression (<0.05) and gait (<0.001) ratings.
|
31079063 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
This retrospective cohort study analyzed data from 474 non-demented patients with de novo Parkinson's disease (mean age, 64.6±9.8 years; 242 men) who underwent both dopamine transporter PET scan and depression assessment using the Beck Depression Inventory at baseline.
|
30231066 |
2018 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Tentatively, this evidence suggests a model where an elevation in striatal D2/3 receptor availability would lead to increased dopaminergic neurotransmission and mania, whilst increased striatal dopamine transporter (DAT) levels would lead to reduced dopaminergic function and depression.
|
28289283 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alterations of striatal DAT and D2/3 receptor binding in CD patients are related mainly to depression.
|
28314910 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that adverse intrauterine environments leading to low birth weight also seem to exacerbate the effects of certain DAT1 variants on depression.
|
26991370 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT and the DAT regulate dopamine availability in the prefrontal cortex and the striatum, respectively, two key regions recruited during learning, whereas dopamine D1 and D2 receptors are thought to be involved in long-term potentiation and depression, respectively.
|
26419600 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (ηp(2)=.065) and depression (ηp(2)=.059), and for DRD2 rs2283265, depression (ηp(2)=.053).
|
24780147 |
2014 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (ηp(2)=.065) and depression (ηp(2)=.059), and for DRD2 rs2283265, depression (ηp(2)=.053).
|
24780147 |
2014 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls.
|
24439516 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls.
|
24439516 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Direct associations were identified between the dopamine receptor 3 (DRD3) BalI polymorphism and depression; the dopamine receptor 1 (DRD1) and dopamine transporter gene 3' VNTR polymorphisms and aberrant motor behavior; the DRD4 VNTR and sleep disturbances; and the SERT gene VNTR 5HTTLPR and apathy items.
|
20685009 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Direct associations were identified between the dopamine receptor 3 (DRD3) BalI polymorphism and depression; the dopamine receptor 1 (DRD1) and dopamine transporter gene 3' VNTR polymorphisms and aberrant motor behavior; the DRD4 VNTR and sleep disturbances; and the SERT gene VNTR 5HTTLPR and apathy items.
|
20685009 |
2012 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.
|
19368898 |
2009 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.
|
19368898 |
2009 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD.
|
18973248 |
2009 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
DAT VNTR 10/10 genotype may be associated with an endophenotype of late-life depression with executive dysfunction that responds preferentially to methylphenidate added to a selective serotonin reuptake inhibitor, which warrants replication in a large sample.
|
17621383 |
2008 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using a gene-by-environment (G x E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression.
|
18181793 |
2008 |