Cocaine Dependence
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We found that patients with genetically higher DAT levels had better treatment outcomes with disulfiram pharmacotherapy of cocaine dependence than those with lower DAT levels.(Am J Addict 2019;28:311-317).
|
31087723 |
2019 |
Cocaine Dependence
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of Arc, CDK5 and TH, and decrease in DAT protein levels persisted longer after withdrawal, pointing to a neuroplastic lasting effect similar to that involved in cocaine addiction.
|
30321610 |
2019 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data describe the behavioral consequence of cocaine tolerance, provide a putative mechanism for its development, and suggest that compounds that disperse DAT complexes may be efficacious treatments for cocaine addiction.
|
29175958 |
2018 |
Cocaine Dependence
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
<b>Background:</b> Preclinical and clinical data suggest that a compound which binds potently to and inhibits the dopamine transporter, but with a slower onset and offset rate than cocaine and with less abuse potential and psychomotor stimulant activity, could be a useful adjunct in the treatment of cocaine dependence.
|
30042675 |
2018 |
Cocaine Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between the Intron 8 VNTR Polymorphism of the DAT1 Gene and Crack Cocaine Addiction.
|
29332099 |
2017 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function.
|
21150910 |
2011 |
Cocaine Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD.
|
20170711 |
2010 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls.
|
20505554 |
2010 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
BEFREE |
Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results.
|
20801583 |
2010 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results.
|
20801583 |
2010 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD.
|
20170711 |
2010 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
BEFREE |
Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample.
|
20505554 |
2010 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
CTD_human |
Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter.
|
19602552 |
2009 |
Cocaine Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively.
|
19462300 |
2009 |
Cocaine Dependence
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter.
|
19602552 |
2009 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively.
|
19462300 |
2009 |
Cocaine Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined the influence of functional genetic variants in DAT1 on cocaine addiction.
|
16537431 |
2006 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
CTD_human |
We examined the influence of functional genetic variants in DAT1 on cocaine addiction.
|
16537431 |
2006 |
Cocaine Dependence
|
0.600 |
Therapeutic
|
disease |
CTD_human |
We examined the influence of functional genetic variants in DAT1 on cocaine addiction.
|
16537431 |
2006 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
BEFREE |
The successful intervention into alcohol dependence and craving brought about by baclofen in both human and animal studies elucidates glutamatergic mechanisms in alcoholism whereas the role of the dopamine transporter, in conjunction with both the noradrenergic and serotonergic transporters, are implicated in cocaine dependence and craving.
|
15545018 |
2004 |
Cocaine Dependence
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys.
|
11746736 |
2002 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
CTD_human |
Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys.
|
11746736 |
2002 |
Cocaine Dependence
|
0.600 |
Biomarker
|
disease |
CTD_human |
Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference.
|
11320258 |
2001 |
Cocaine Dependence
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference.
|
11320258 |
2001 |