|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTTLPR and <i>MTHFR 677C</i>>T polymorphisms and response to yoga-based lifestyle intervention in major depressive disorder: A randomized active-controlled trial.
|
30581206 |
2020 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
49 patients with major depression and SSRI treatment were genotyped for the 5-HTTLPR locus including the rs25531.
|
22086748 |
2012 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression.
|
26974654 |
2016 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The specific genetic locus causing serotonin uptake to be lower in some patients with major depression involves a polymorphic region (5-HTTLPR) in the promoter region of the gene for the uptake protein.
|
15877307 |
2005 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
CTD_human |
The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure.
|
18686203 |
2008 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
A diffuse reduction of 5-HTT binding in the PFC of individuals with major depression may reflect a widespread impairment of serotonergic function consistent with the range of psychopathologic features in major depression.
|
10920459 |
2000 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population.
|
27212180 |
2016 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
High-risk individuals (high hurricane exposure, the low-expression 5-HTTLPR variant, low social support) were at 4.5 times the risk of developing PTSD and major depression of low-risk individuals.
|
17974934 |
2007 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study included 2679 participants.Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018).
|
25510949 |
2015 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
We found that healthy controls have a strong association between the 5-HTTLPR and GM volumes of the dorsolateral prefrontal cortex, left anterior gyrus cinguli, left amygdala as well as right hippocampus, whereas there is no such association in patients with major depression.
|
19008895 |
2008 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness.
|
7711157 |
1995 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5-HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression.
|
20047709 |
2010 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall our results suggest that the investigated 5-HT2A and 5-HTTLPR polymorphisms are not major susceptibility factors in the etiology of major depression.
|
11311507 |
2001 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression.
|
25650523 |
2015 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
We sought to test further the hypothesis that SLC6A4 is associated with SSRI response by resequencing this gene in subjects with major depression.
|
15993855 |
2005 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neuroticism accounted for 42.3% of the effect of 5HTT-LPR genotype on lifetime major depression, indicating possible mediation (p<0.001).
|
16319503 |
2006 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Characterizing risk for major depression and generalized anxiety syndrome in the last year as a function of 5-HTT genotype, sex, and the occurrence of SLEs and ratings of the SLE-associated level of threat.
|
15867106 |
2005 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The majority of the volume enlargement associated with the SERT-ss genotype occurred in the pulvinar, whereas enlargement associated with major depressive disorder occurred in the limbic nuclei and in other regions of the thalamus.
|
18378990 |
2008 |
|
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Down regulation of serotonin transporter (5-HTT) expression has been associated with brain function and major depression.
|
23017007 |
2013 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Results show that 5-HTTLPR is strongly associated with the major depressive disorder in postpartum women.
|
24882202 |
2014 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Findings indicate a significant association between 5-HTTLPR short variant genotype and poststroke major depression.
|
16525076 |
2006 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression.
|
23149035 |
2013 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, variability in the SERT gene was analyzed for the first time in a sample of patients with major depression with melancholia (MDDM) in the context of a genetic association study.
|
9799087 |
1998 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.
|
24911443 |
2014 |