Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS).
|
11335745 |
2001 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In our recent study allele variants in the promoter of serotonin transporter (5-HTT) gene have been shown as a novel risk factor for sudden infant death syndrome (SIDS).
|
12018976 |
2002 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
CTD_human |
These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence.
|
12599191 |
2003 |
Sudden infant death syndrome
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These data, if confirmed in larger studies, may begin to explain the differences in SIDS incidence by ethnicity, suggest a role for levels of 5-HTT expression in generation of SIDS susceptibility, and provide an important tool for identifying at-risk individuals and estimating the risk of recurrence.
|
12966525 |
2003 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
These results indicate a relationship between SIDS and the 12-repeat allele of the intron 2 variable number tandem repeat of the 5-HTT gene in African-Americans, and a significant role of the haplotype containing the 12-repeat allele and the promoter L-allele in defining SIDS risk in African-Americans.
|
12966525 |
2003 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence.
|
12599191 |
2003 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
These results indicate a relationship between SIDS and the 12-repeat allele of the intron 2 variable number tandem repeat of the 5-HTT gene in African-Americans, and a significant role of the haplotype containing the 12-repeat allele and the promoter L-allele in defining SIDS risk in African-Americans.
|
12966525 |
2003 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
5-HT neuron count and density, 5-HT(1A) receptor binding density, and 5-HT transporter (5-HTT) binding density in the medullary 5-HT system; correlation between these markers and 6 recognized risk factors for SIDS.
|
17077377 |
2006 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
3' UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysis.
|
16691588 |
2006 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS.
|
18477062 |
2008 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
LHGDN |
Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome.
|
18387780 |
2008 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS.
|
18477062 |
2008 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
Findings are discussed considering the metabolic association among DAT, 5-HTT and MAOA with special emphasis on the linked action of 5-HTT/MAOA in regulating serotonin metabolism of SIDS and SIUD infants.
|
18810510 |
2009 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
One of the candidate genes is the serotonin transporter (5-HTT) gene, based on decreased serotonergic receptor binding observed in the brain-stems of SIDS victims.
|
19261524 |
2009 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
MGD |
Overall, our findings provide i) new insights into the role of SERT gene in SIDS, and ii) the first in vivo validation of the molecular mechanism involving the activation of TGF-beta1 signalling in the cardiac fibrosis.
|
19646988 |
2009 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS.
|
20661167 |
2010 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
Despite its functional role, results highlight the usefulness of 5HTT as a valuable tracer of SIDS risk in IALTE infants.
|
22711722 |
2012 |
Sudden infant death syndrome
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Using qRT-PCR we studied the gene expression of 5-HTT in ten SIDS cases, previously analyzed at a molecular level and which showed the genetic S/S profile.
|
22771822 |
2013 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This article indicates that neither the VNTR in the promoter of the MAOA gene, nor rs25531 in the gene encoding 5-HTT, is involved in SIDS.
|
24286237 |
2014 |