|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a candidate for vulnerability to psychiatric disorders.
|
10673774 |
2000 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We have recently described a polymorphism in the 5-HTT gene promoter (5-HTTLPR) which influences the function of the 5-HTT and is associated with several psychiatric disorders.
|
10676853 |
2000 |
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Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
There is abundant evidence that the serotonin (5-HT) system is modulating mood and several behavioural traits and that disturbances in the regulation of this system can be associated with severe behavioural malfunctions, as aggressive implusive and suicidal behaviour.1 Recently a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was identified2 and the presence of one or two short alleles was associated with anxiety-related personality traits3 and several psychiatric disturbances, such as affective disorder4 or severe alcohol dependence.5 With respect to the importance of the 5-HT transporter in serotonergic transmission, we have genotyped the DNA of 58 Caucasian suicide victims (with unknown psychiatric diagnoses) and 110 healthy controls for the biallelic functional polymorphism in the 5-HTTLPR.
|
10822348 |
2000 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin transporter gene (SLC6A4), which plays a key role in the serotonergic pathway in the brain, is a candidate for mediating genetic susceptibility to various psychiatric disorders.
|
11324943 |
2000 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A functional polymorphism (5-HTTLPR) in the upstream regulatory region of the gene (SLC6A4) has been associated with a number of psychiatric disturbances, but conflicting replication followed.
|
11803453 |
2002 |
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Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies.
|
12218657 |
2002 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms.
|
12860364 |
2003 |
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Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A serotonin transporter promoter polymorphism (5-HTTLPR) has been extensively studied in neuroticism and several psychiatric disorders, with inconclusive results.
|
14744464 |
2004 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Alterations in the serotonin transporter (5-HTT) have been implicated in a variety of psychiatric disorders including cocaine dependence.
|
15091312 |
2004 |
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Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A functional length variation in the transcriptional control region of the serotonin transporter gene (5-HTTLPR) influences brain function, personality traits, and susceptibility to psychiatric disorders.
|
15187981 |
2004 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin transporter (5-HTT) and tryptophan hydroxylase (TPH) gene are important candidate genes for the psychiatric disorders.
|
15722951 |
2005 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Serotonin transporter gene (SLC6A4) is one of the most promising candidate genes for psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BP).
|
16082508 |
2006 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The role of the human serotonin transporter protein (5-HTT) gene in psychiatric disorders suggests that its variation may influence the comorbidity pattern and the heterogeneity of alcoholism.
|
16691130 |
2006 |
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Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
It was demonstrated that polymorphisms in the promoter region (5-HTTLPR) and in the second intron (VNTR) have functional consequences and are for this reason of particular interest in relation to various psychiatric disorders.
|
16969272 |
2006 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) genes have shown positive associations with obsessive-compulsive disorder (OCD) and some other psychiatric disorders, but these results have not been consistently replicated.
|
17375136 |
2007 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We have demonstrated in both the human serotonin transporter gene (5HTT) and the dopamine transporter gene (DAT1) that specific polymorphic variants termed Variable Number Tandem Repeats (VNTRs), which correlate with predisposition to a number of neurological and psychiatric disorders, act as transcriptional regulatory domains.
|
17960477 |
2008 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin transporter gene (SLC6A4) encodes a trans-membrane protein (5-HTT) that plays an important role in regulating serotonergic neurotransmission, which is known to be involved in many psychiatric disorders.
|
18349696 |
2008 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The newly derived 5-HTTLPR Phenotype Scale shows strong association with 5-HTTLPR genotype and phenotype, therefore this scale should be further investigated in relation to psychiatric disorders, as well as psychological traits and temperaments.
|
18455241 |
2009 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results thus yield further insight into the role of the 5-HTTLPR in the background of neuroticism and neuroticism-related psychiatric disorders.
|
18806915 |
2009 |
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Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Therefore, the presence of comorbid psychiatric disorders should be taken into account to clarify the association of the 5-HTTLPR polymorphism with MDD phenotypes.
|
19125107 |
2009 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A functional polymorphism in the promoter region of the 5-HTT gene (5-HTTLPR) has been associated with several psychiatric disorders as well as anxiety-related personality traits.
|
19126263 |
2009 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Comparing the genotypic and allelic frequencies of AD without and with BPSD, we did not find a difference for the 5-HTTLPR or the rs25531, even after stratification according to single SBI-BP item.
|
19625753 |
2009 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Serotonin transporter (SERT, 5-HTT) is a key element in the serotonergic system which is probably involved in the psychiatric disorders commonly observed in people living with HIV/AIDS.
|
19854262 |
2010 |
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Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The S allele has been associated with a variety of psychiatric disorders and symptoms including alcohol dependence, but it is unknown whether 5-HTTLPR increases the risk for co-morbid sociopathy among those with alcohol dependence.
|
20192950 |
2011 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The serotonin transporter promoter length polymorphism (5-hydroxytryptamine transporter length polymorphism; 5-HTTLPR) has long been implicated in autism and other psychiatric disorders.
|
20649385 |
2010 |