Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNF Val66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers compared to the other allelic groups.
|
30711709 |
2019 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The present findings hint towards distinct mechanisms mediating the influence of 5-HTTLPR/rs25531 genotype on depressive symptoms and anxiety, with negative life events playing a crucial role in both phenotypes.
|
31422473 |
2019 |
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
5-HTT knockout mice, lacking the 5-HTT gene either homo- or heterozygously, provide a widely used model organism for the study of symptoms related to human anxiety disorders.
|
31849623 |
2019 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Antidepressants that block the serotonin transporter, (Slc6a4/SERT), selective serotonin reuptake inhibitors (SSRIs) improve mood in adults but have paradoxical long-term effects when administered during perinatal periods, increasing the risk to develop anxiety and depression.
|
30279456 |
2019 |
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
However, G x E interactions of 5-HTTLPR with high emotional impact and prior lifetime anxiety disorders were statistically significant.
|
31727442 |
2019 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in genes coding for the serotonin receptor subtype 1A (HTR1A), the serotonin transporter (SLC6A4), and the serotonin degrading enzyme monoamine oxidase A (MAOA) are associated with anxiety, impulsivity, and neurotic personality in humans.
|
31045220 |
2019 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Previously it was shown that healthy individuals with the short allelic variant ('s-group') of the 5-HTTLPR-polymorphism displayed more anxiety and negative mood, and had a lower transcriptional efficiency compared to individuals who are homozygous for the l-allele ('l-group').
|
29348651 |
2018 |
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
Along with being the main target of many antidepressant medications, the serotonin transporter (5-HTT) is known to be involved in the pathophysiology of depression and anxiety disorders.
|
28629963 |
2017 |
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
We show that 5-HTTLPR predicts higher impulsivity, hostility, and neuroticism, and that impulsivity could serve as a useful independent outcome or intermediary phenotype in genetic studies of anxiety.
|
28391138 |
2017 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental disorders such as anxiety and depression, moderates the associations between a cultural trait (i.e., interdependence) and self-report of death anxiety/depression and between interdependence and brain responses to mortality threats.
|
28921740 |
2017 |
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
In the present study, the number of 5-HT- and TPH-positive cells, and expression of 5-HT<sub>1A</sub> and 5-HTT protein decreased in dorsal raphe, and depression and anxiety like behavior increased in HFD group compared with the CON group.
|
28142069 |
2017 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This SNP is located within the serotonin transporter gene SLC6A4, which is the primary target of selective-serotonin reuptake inhibitors used for the treatment of depressive and anxiety disorders.
|
28272115 |
2017 |
Anxiety Disorders
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In humans, the short (S) allele in the 5-HTT gene-linked polymorphic region, which decreases 5-HTT expression, has been shown to be associated with behavioral changes including an increased level of anxiety.
|
28465138 |
2017 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The interaction between the serotonin transporter (SERT) linked polymorphic region (5-HTTLPR) and adverse early life stressing (ELS) events is associated with enhanced stress susceptibility and risk to develop mental disorders like major depression, anxiety, and aggressiveness.
|
28491024 |
2017 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We used different statistical analyses to test co-development of cannabis use and symptoms of anxiety throughout adolescence and the possible role of the 5-HTTLPR genotype in this process.
|
26860734 |
2017 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
IBS patients with depressive disorders were characterized by higher frequency of 5-HTTLPR L allele in comparison to IBS patients with anxiety disorders.
|
28951738 |
2017 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The Relationship between Personality Traits, the 5HTT Polymorphisms, and the Occurrence of Anxiety and Depressive Symptoms in Elite Athletes.
|
27257942 |
2016 |
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
We explored this issue in 371 preschoolers and their caregivers, examining whether parent characteristics (i.e., overinvolvement or anxiety disorder) and child 5-HTTLPR influenced the continuity of BI between ages 3 and 5.
|
27739394 |
2016 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The study did not demonstrate the relationship between the 5-HTT and MAO-A gene polymorphisms, and the severity of anxiety and mood disorders in healthy late-reproductive-stage women.
|
27614969 |
2016 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Influence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study.
|
27145764 |
2016 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The distribution of 5-HTT gene polymorphisms in the healthy group, the group with asthma but without anxiety, and the group with asthma and anxiety had significant differences.
|
27176146 |
2016 |
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
Moreover, the 5-HTTLPR association with RRS was mediated by the RVPFC activity and the 5-HTTLPR association with social interaction anxiety was mediated by both the dorsal-rostral ACC connectivity and RVPFC activity.
|
26385612 |
2016 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The lower-expressing (S') alleles of the serotonin transporter (5-HTT) gene promoter polymorphism (5-HTTLPR) are linked to mood and anxiety related psychopathology.
|
26561939 |
2016 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The serotonin transporter length polymorphism (5-HTTLPR) short allele (5-HTTLPR-s) has been associated with differential susceptibility for anxiety and depression in multiple psychiatric disorders.
|
26509115 |
2015 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Thus, our results provide further evidence that 5-HTTLPR and COMT Val(158)Met genotypes influence the vulnerability for the development of anxiety disorders via different mechanisms.
|
25455425 |
2015 |