SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis. 30217771 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE HR-BD youth with the s-allele of the 5-HTTLPR gene may be at greatest risk for developing BD. 28667891 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE Putatively detrimental effects of childhood trauma exposure on adult BDNF serum levels are influenced by 5-HTTLPR genotype in patients affected by BD. 28754344 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE The effects of 5-HTTLPR on the anomalous emotional processing in BD might be mediated by changes of WM microstructure in key WM tracts contributing to the functional integrity of the brain. 25704032 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE Only antianxiety medication naïve offspring of BD parents were found to have an association between 5-HTTLPR genotypes and anxiety symptoms. 26218602 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease PSYGENET Finally, bisulfite-sequencing analysis revealed that quetiapine decreased the DNA methylation level of the promoter region of SLC6A4, where hypermethylation with bipolar disorder and hypomethylation with mood stabilizers have been reported. 25194461 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE Age at onset (AAO) of bipolar disorders (BD) could be influenced both by a repeat length polymorphism (5HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A4) and exposure to childhood trauma. 26542422 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE 5-HTTLPR modulated the relationship between early life stress and the core features of bipolar illness. 25219494 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease PSYGENET Abnormal expression and genetic polymorphism of SLC6A3 and SLC6A4 genes may increase the risk of developing mental illness, such as schizophrenia, bipolar disorder, ADHD, and aggressive behavior in Alzheimer disease, etc. 25019689 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder. 23410635 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 PosttranslationalModification disease BEFREE Several disease-associated changes in methylation have been reported: hypermethylation of SOX10 in schizophrenia, hypomethylation of HCG9 (HLA complex group 9) in bipolar disorder, hypermethylation of PRIMA1, hypermethylation of SLC6A4 (serotonin transporter) in bipolar disorder, and hypomethylation of ST6GALNAC1 in bipolar disorder. 24389572 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE A total of sixty-three genetic variants were selected on the basis of previous GWASs of MDD, SCZ, and BD as well as candidate-gene (SLC6A4, BDNF, DBH, and FKBP5) studies. 25517604 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Since genetic polymorphisms and epigenetic dysregulation of 5-HTT are involved in the pathogenesis of mental diseases, we analyzed DNA methylation of 5-HTT promoter in post-mortem brains and saliva samples of patients with schizophrenia (SCZ) and bipolar disorder (BD) to evaluate its potential application as a diagnostic and/or therapeutic biomarker in SCZ and BD. 24411530 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease PSYGENET We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder. 24229495 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder. 24229495 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease PSYGENET 5-HTTLPR modulated the relationship between early life stress and the core features of bipolar illness. 25219494 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease PSYGENET However, we found that CpG sites of SLC6A4, which were hypermethylated in patients with bipolar disorder, were hypomethylated in the neuroblastoma cells treated with mood stabilizers. 23931339 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE Study of the association of serotonin transporter triallelic 5-HTTLPR and STin2 VNTR polymorphisms with lithium prophylaxis response in bipolar disorder. 23277128 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE However, we found that CpG sites of SLC6A4, which were hypermethylated in patients with bipolar disorder, were hypomethylated in the neuroblastoma cells treated with mood stabilizers. 23931339 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE The short allele (S allele) of 5-HTTLPR showed a significant association with bipolar disorder in our meta-analysis (odds ratio=1.10, p-value=0.005), suggesting it is likely a risk polymorphism for the illness, and the observed OR is consistent with other susceptibility loci identified through recent large-scale genetic association studies on bipolar disorder, which could be regarded simply as a small but detectable effects. 23756178 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 PosttranslationalModification disease BEFREE This is the first study to report the role of epigenetic modification of SLC6A4 in BD using an unbiased approach, which provides an insight for its pathophysiology. 22832526 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE These data do not support a role for differential allelic expression of 5HTT for suicidal behaviour in bipolar disorder. 21290142 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE The 5-HTTLPR polymorphism appears to have a moderate effect size association with AIM in patients with bipolar disorder. 21040287 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE The gene coding for the 5-HT transporter (5-HTT) is considered as a candidate gene for bipolar disorder, either as a "vulnerability" or as a "modifying the phenotype" gene. 20434316 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population. 18792946 2009