|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
Repeated exposure to mixed-action DAT≈SERT substrates such as mephedrone can result in increased abuse potential due to sustained expression of DAT-mediated abuse-related effects and tolerance to SERT-mediated abuse-limiting effects.
|
30232529 |
2019 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events.
|
27701012 |
2017 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our study included 2679 participants.Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018).
|
25510949 |
2015 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The SS genotype of the serotonin transporter gene (5-HTTLPR) was associated with high levels of impulsivity when the subjects reported emotional abuse [odds ratio (OR) 5.55, 95% confidence interval (CI) 1.75-17.5] or physical abuse (OR 5.03, 95% CI 1.50-16.9) in their childhood.
|
25065374 |
2014 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
In multivariable logistic regression analysis, an interaction between abuse and 5-HTTLPR group was significantly associated with non-change status, along with partner communication frequency scores at follow-up.
|
23479192 |
2014 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life.
|
25214390 |
2014 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Significant four-way interactions were found for BDNF Val66Met × 5-HTTLPR×MAOA-uVNTR × family conflicts and for BDNF Val66Met × 5-HTTLPR×MAOA-uVNTR × sexual abuse.
|
25522433 |
2014 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Consequently, we examined how serotonin transporter (5-HTTLPR) polymorphisms, monoamine oxidase-A (MAO-A) variants, and childhood abuse measured with the Childhood Trauma Questionnaire relate to dimensions of psychopathy in a forensic sample of 237 men with elevated levels of environmental adversity.
|
22985017 |
2013 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For the four MDD outcome measures, we examined the direct effects of 5-HTTLPR/rs25531-haplotypes, five environmental factors (lifetime and recent stressful life-events, sexual abuse, low educational attainment, and childhood trauma) and their interaction in logistic regression models.
|
23021380 |
2013 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
The meta-analyses support the associations of 5-HTTLPR with alcohol, heroin, cocaine, and methamphetamine dependence and abuse (eg, the smallest P-values were 0.0058 with odds ratio (OR)=0.54 (0.35, 0.84); 0.0024 with OR=0.77 (0.66, 0.91); 0.018 with OR=1.38 (1.06, 1.81); and 0.028 with OR=0.46 (0.23, 0.92) for alcohol, heroin, cocaine, and methamphetamine dependence/abuse, respectively).
|
23518607 |
2013 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Significant interactions with additive and recessive 5-HTTLPR genetic models were found for overall severity of maltreatment, sexual abuse and to a lesser degree for physical neglect, but not other maltreatment types.
|
22840631 |
2013 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
The interaction effect of the 5-HTTLPR and the past sexual abuse was also observed on drive for thinness.
|
22018958 |
2012 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results point to a gene-gene-environment interaction that relevantly impacts on the role of the s/s genotype of the 5-HTTLPR in childhood abuse: Depending on the BDNF background (Val/Val versus Met allele) the s/s genotype showed either protective or risk properties with regard to depressive symptoms.
|
21996278 |
2012 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Global three-way interactions among the 5-HTTLPR, adult traumatic experiences and childhood abuse (P = 0.0007) were found.
|
22328412 |
2012 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We observed a significant interaction between 5-HTTLPR variants and childhood trauma across cognitive domains; here, homozygotic s-carriers exposed to high levels of childhood trauma (physical neglect and abuse) had significantly poorer cognitive functioning than all other groups.
|
21908796 |
2012 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In earlier analyses of nonHispanic White women we found a stronger relation between abuse history and midpregnancy elevated depressive symptoms in women with the serotonin transporter (5-HTTLPR) S/S genotype.
|
22030619 |
2011 |
|
Drug abuse
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Replicating prior work, we found that a significant effect of childhood sex abuse on methylation of the 5HTT promoter region emerged for women.
|
20947778 |
2011 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We investigated the 5-HTTLPR of the 5-HTT gene (G) and the presence of childhood sexual abuse and cannabis comorbidity (E) in 137 bipolar patients with (versus without) lifetime psychotic symptoms.
|
20434316 |
2010 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
The human serotonin (5-hydroxytryptamine) transporter, encoded by the SLC6A4 gene on chromosome 17q11.1-q12, is the cellular reuptake site for serotonin and a site of action for several drugs with central nervous system effects, including both therapeutic agents (e.g. antidepressants) and drugs of abuse (e.g. cocaine).
|
19351213 |
2009 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
CTD_human |
Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression.
|
19272758 |
2009 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Reported childhood abuse is associated with lower 5-HTT BP(P) in this sample of subjects with major depression, consistent with other reports that childhood adversity can lower serotonergic function permanently.
|
19288578 |
2009 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The high-comorbidity class displayed significantly higher dieting preoccupations and conduct problems, and showed a greater likelihood of carrying the 5-HTTLPR S allele and of childhood abuse than did the low-comorbidity class.
|
18505306 |
2008 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sexual abuse and the 5-HTT short/short genotype predicted higher depression, anxiety, and somatic symptoms.
|
17931441 |
2007 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There is growing evidence that a functional polymorphism in the serotonin transporter gene (5-HTTLPR) moderates the impact of negative life events (e.g., childhood abuse) on the development of depression.
|
17250473 |
2006 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
The serotonin transporter (5-HTT) regulates serotonin transmission and modulates behavioral effects of drug of abuse.
|
16109588 |
2005 |