Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype RGD Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats. 19473340 2009
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype CTD_human Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. 18506000 2008
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype RGD [Chronic administration of serotonin transporter inhibitor (fluoxetine) decreases monocrotaline-induced pulmonary hypertension in rats]. 18074800 2008
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 AlteredExpression phenotype LHGDN Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. 16614302 2006
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 GeneticVariation phenotype LHGDN We have tested the hypothesis that the 5HTT gene does contribute to the pathogenesis of this disease in children by comparing the allelic frequencies of both the long and short variants between children with idiopathic pulmonary hypertension and pulmonary hypertension secondary to underlying pulmonary disease. 16009349 2005
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 GeneticVariation phenotype LHGDN In patients carrying the LL genotype, which is associated with higher levels of 5-HTT expression in pulmonary artery smooth muscle cells than the LS and SS genotypes, PH was more severe than in LS or SS patients. 14530202 2003
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype RGD These data show that, in rats, the increased 5-HTT expression that follows dexfenfluramine discontinuation promotes the development of hypoxic pulmonary hypertension. 11259539 2001